TY - JOUR
T1 - CT Enterography score
T2 - A potential predictor for severity assessment of active ulcerative colitis
AU - Jia, Yingmei
AU - Li, Chang
AU - Yang, Xiaoyan
AU - Dong, Zhi
AU - Huang, Kun
AU - Luo, Yanji
AU - Li, Xuehua
AU - Sun, Canhui
AU - Feng, Shi Ting
AU - Li, Zi Ping
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/11/9
Y1 - 2018/11/9
N2 - Background: Evaluate the possibility of CT enterography (CTE) score system as a predictor in assessing active ulcerative colitis (UC) severity. Methods: Forty-six patients with active UC with CTE and colonoscopy were enrolled. Based on modified Mayo score, patients were divided into three groups: mild (n = 10), moderate (n = 17) and severe (n = 19). A cumulative CTE score was calculated in each patient and its correlation with modified Mayo score was analyzed. The optimal cutoff values of CTE score were determined by receiver operating characteristic (ROC) curves analysis. Results: Significant between-group differences were observed in CTE spectrums of mucosal bubbles, mural stratification, loss of haustration, enlarged mesenteric lymph nodes and engorged mesenteric vessels (P < 0.05). The cumulative CTE scores were significant difference between three groups (CTE score:4.9 ± 2.3, 7.6 ± 2.6, and 10.9 ± 2.0, respectively, P < 0.01). The cumulative CTE score showed a positive correlation with modified Mayo score (r = 0.835, P < 0.05). The optimal cut-off value for CTE score predicting moderate and severe UC was 9.5 (area under the curve [AUC]:0.847, sensitivity:78.9%, specificity:82.4%). Conclusion: Disease severity assessment by CTE score demonstrates strong positive correlation with severity established modified Mayo score. CTE score system maybe a potential predictor for active UC severity assessment.
AB - Background: Evaluate the possibility of CT enterography (CTE) score system as a predictor in assessing active ulcerative colitis (UC) severity. Methods: Forty-six patients with active UC with CTE and colonoscopy were enrolled. Based on modified Mayo score, patients were divided into three groups: mild (n = 10), moderate (n = 17) and severe (n = 19). A cumulative CTE score was calculated in each patient and its correlation with modified Mayo score was analyzed. The optimal cutoff values of CTE score were determined by receiver operating characteristic (ROC) curves analysis. Results: Significant between-group differences were observed in CTE spectrums of mucosal bubbles, mural stratification, loss of haustration, enlarged mesenteric lymph nodes and engorged mesenteric vessels (P < 0.05). The cumulative CTE scores were significant difference between three groups (CTE score:4.9 ± 2.3, 7.6 ± 2.6, and 10.9 ± 2.0, respectively, P < 0.01). The cumulative CTE score showed a positive correlation with modified Mayo score (r = 0.835, P < 0.05). The optimal cut-off value for CTE score predicting moderate and severe UC was 9.5 (area under the curve [AUC]:0.847, sensitivity:78.9%, specificity:82.4%). Conclusion: Disease severity assessment by CTE score demonstrates strong positive correlation with severity established modified Mayo score. CTE score system maybe a potential predictor for active UC severity assessment.
KW - Computed tomography enterography
KW - Disease activity
KW - Modified Mayo score
KW - Multi-slice computed tomography
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85056423903&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056423903&partnerID=8YFLogxK
U2 - 10.1186/s12876-018-0890-z
DO - 10.1186/s12876-018-0890-z
M3 - Article
C2 - 30413186
AN - SCOPUS:85056423903
SN - 1471-230X
VL - 18
JO - BMC Gastroenterology
JF - BMC Gastroenterology
IS - 1
M1 - 173
ER -