CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection

Rebecca Waitz; Marcella Fassò; James P. Allison

doi:10.4161/onci.19442

CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection

Rebecca Waitz, Marcella Fassò, James P. Allison

Research output: Contribution to journal › Comment/debate › peer-review

30 Scopus citations

Abstract

We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8⁺ T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.

Original language	English (US)
Pages (from-to)	544-546
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/onci.19442
State	Published - 2012
Externally published	Yes

Keywords

CTLA-4
Cryoablation
Ipilumimab
Prostate cancer
SPAS-1

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.19442

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title = "CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection",

abstract = "We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8+ T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.",

keywords = "CTLA-4, Cryoablation, Ipilumimab, Prostate cancer, SPAS-1",

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AU - Waitz, Rebecca

AU - Fassò, Marcella

AU - Allison, James P.

PY - 2012

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N2 - We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8+ T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.

AB - We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8+ T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.

KW - CTLA-4

KW - Cryoablation

KW - Ipilumimab

KW - Prostate cancer

KW - SPAS-1

UR - http://www.scopus.com/inward/record.url?scp=84885714781&partnerID=8YFLogxK

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U2 - 10.4161/onci.19442

DO - 10.4161/onci.19442

M3 - Comment/debate

C2 - 22754781

AN - SCOPUS:84885714781

SN - 2162-4011

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EP - 546

JO - OncoImmunology

JF - OncoImmunology

IS - 4

ER -

CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection

Abstract

Keywords

ASJC Scopus subject areas

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