Curing hepatocellular carcinomatosis with biologic therapy and surgery: Achieving the impossible?

Melanie B. Thomas; Eric Tetzlaff; Richard Lozano; Leigh Samp; Charles E. Butler; Christopher Gannon; Stanley Hamilton; Jean Nicholas Vauthey; Eddie Abdalla

doi:10.1002/jso.20898

Curing hepatocellular carcinomatosis with biologic therapy and surgery: Achieving the impossible?

Melanie B. Thomas, Eric Tetzlaff, Richard Lozano, Leigh Samp, Charles E. Butler, Christopher Gannon, Stanley Hamilton, Jean Nicholas Vauthey, Eddie Abdalla

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) that present as hemoperitoneum are uncommon, often recur as peritoneal carcinomatosis, and have poor prognosis. Systemic chemotherapies are minimally effective in advanced HCC and less so as neo-adjuvant therapy. This report describes a 47-year woman with ruptured HCC who developed recurrent carcinomatosis. She received biologically targeted systemic therapy which resulted in significant radiographic tumor response. Salvage surgery revealed complete pathologic response in all tumor nodules, thus the patient was rendered cancer-free.

Original language	English (US)
Pages (from-to)	82-84
Number of pages	3
Journal	Journal of surgical oncology
Volume	97
Issue number	1
DOIs	https://doi.org/10.1002/jso.20898
State	Published - Jan 1 2008

Keywords

Hepatocellular carcinoma
Resection
Targeted chemotherapy

ASJC Scopus subject areas

Surgery
Oncology

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title = "Curing hepatocellular carcinomatosis with biologic therapy and surgery: Achieving the impossible?",

abstract = "Hepatocellular carcinoma (HCC) that present as hemoperitoneum are uncommon, often recur as peritoneal carcinomatosis, and have poor prognosis. Systemic chemotherapies are minimally effective in advanced HCC and less so as neo-adjuvant therapy. This report describes a 47-year woman with ruptured HCC who developed recurrent carcinomatosis. She received biologically targeted systemic therapy which resulted in significant radiographic tumor response. Salvage surgery revealed complete pathologic response in all tumor nodules, thus the patient was rendered cancer-free.",

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AU - Thomas, Melanie B.

AU - Tetzlaff, Eric

AU - Lozano, Richard

AU - Samp, Leigh

AU - Butler, Charles E.

AU - Gannon, Christopher

AU - Hamilton, Stanley

AU - Vauthey, Jean Nicholas

AU - Abdalla, Eddie

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N2 - Hepatocellular carcinoma (HCC) that present as hemoperitoneum are uncommon, often recur as peritoneal carcinomatosis, and have poor prognosis. Systemic chemotherapies are minimally effective in advanced HCC and less so as neo-adjuvant therapy. This report describes a 47-year woman with ruptured HCC who developed recurrent carcinomatosis. She received biologically targeted systemic therapy which resulted in significant radiographic tumor response. Salvage surgery revealed complete pathologic response in all tumor nodules, thus the patient was rendered cancer-free.

AB - Hepatocellular carcinoma (HCC) that present as hemoperitoneum are uncommon, often recur as peritoneal carcinomatosis, and have poor prognosis. Systemic chemotherapies are minimally effective in advanced HCC and less so as neo-adjuvant therapy. This report describes a 47-year woman with ruptured HCC who developed recurrent carcinomatosis. She received biologically targeted systemic therapy which resulted in significant radiographic tumor response. Salvage surgery revealed complete pathologic response in all tumor nodules, thus the patient was rendered cancer-free.

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KW - Resection

KW - Targeted chemotherapy

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Curing hepatocellular carcinomatosis with biologic therapy and surgery: Achieving the impossible?

Abstract

Keywords

ASJC Scopus subject areas

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