Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases

Kimberly McAllister; Leah E. Mechanic; Christopher Amos; Hugues Aschard; Ian A. Blair; Nilanjan Chatterjee; David Conti; W. James Gauderman; Li Hsu; Carolyn M. Hutter; Marta M. Jankowska; Jacqueline Kerr; Peter Kraft; Stephen B. Montgomery; Bhramar Mukherjee; George J. Papanicolaou; Chirag J. Patel; Marylyn D. Ritchie; Beate R. Ritz; Duncan C. Thomas; Peng Wei; John S. Witte

doi:10.1093/aje/kwx227

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases

Kimberly McAllister, Leah E. Mechanic, Christopher Amos, Hugues Aschard, Ian A. Blair, Nilanjan Chatterjee, David Conti, W. James Gauderman, Li Hsu, Carolyn M. Hutter, Marta M. Jankowska, Jacqueline Kerr, Peter Kraft, Stephen B. Montgomery, Bhramar Mukherjee, George J. Papanicolaou, Chirag J. Patel, Marylyn D. Ritchie, Beate R. Ritz, Duncan C. ThomasPeng Wei, John S. Witte

Biostatistics

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Recently, many new approaches, study designs, and statistical and analytical methods have emerged for studying gene-environment interactions (G×Es) in large-scale studies of human populations. There are opportunities in this field, particularly with respect to the incorporation of-omics and next-generation sequencing data and continual improvement in measures of environmental exposures implicated in complex disease outcomes. In a workshop called Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases, held October 17-18, 2014, by the National Institute of Environmental Health Sciences and the National Cancer Institute in conjunction with the annual American Society of Human Genetics meeting, participants explored new approaches and tools that have been developed in recent years for G×E discovery. This paper highlights current and critical issues and themes in G×E research that need additional consideration, including the improved data analytical methods, environmental exposure assessment, and incorporation of functional data and annotations.

Original language	English (US)
Pages (from-to)	753-761
Number of pages	9
Journal	American journal of epidemiology
Volume	186
Issue number	7
DOIs	https://doi.org/10.1093/aje/kwx227
State	Published - Oct 1 2017

Keywords

Environmental exposure
Gene-environment interaction
Genome-wide association study

ASJC Scopus subject areas

Epidemiology

MD Anderson CCSG core facilities

Biostatistics Resource Group

Access to Document

10.1093/aje/kwx227

Cite this

McAllister, K., Mechanic, L. E., Amos, C., Aschard, H., Blair, I. A., Chatterjee, N., Conti, D., Gauderman, W. J., Hsu, L., Hutter, C. M., Jankowska, M. M., Kerr, J., Kraft, P., Montgomery, S. B., Mukherjee, B., Papanicolaou, G. J., Patel, C. J., Ritchie, M. D., Ritz, B. R., ... Witte, J. S. (2017). Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. American journal of epidemiology, 186(7), 753-761. https://doi.org/10.1093/aje/kwx227

McAllister, K, Mechanic, LE, Amos, C, Aschard, H, Blair, IA, Chatterjee, N, Conti, D, Gauderman, WJ, Hsu, L, Hutter, CM, Jankowska, MM, Kerr, J, Kraft, P, Montgomery, SB, Mukherjee, B, Papanicolaou, GJ, Patel, CJ, Ritchie, MD, Ritz, BR, Thomas, DC, Wei, P & Witte, JS 2017, 'Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases', American journal of epidemiology, vol. 186, no. 7, pp. 753-761. https://doi.org/10.1093/aje/kwx227

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AU - Ritchie, Marylyn D.

AU - Ritz, Beate R.

AU - Thomas, Duncan C.

AU - Wei, Peng

AU - Witte, John S.

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Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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