Current chemotherapeutic regimens for brain metastases treatment

Joo Yeon Nam; Barbara J. O’Brien

doi:10.1007/s10585-017-9861-y

Current chemotherapeutic regimens for brain metastases treatment

Joo Yeon Nam, Barbara J. O’Brien

Neuro-Oncology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Brain metastasis is a common complication in advanced systemic cancer, with an increasing incidence. The diagnosis of brain metastasis historically portended a dismal prognosis. The successful development of effective treatments for patients with brain metastasis is complicated by the differences among cancer subtypes, the limited understanding of the underlying pathophysiology of BM, the impact of the blood-brain barrier, and other factors. There is now renewed interest in treating this often devastating complication of cancer, and in understanding the underlying mechanisms of disease in this “sanctuary” site. Promising treatment strategies include brain-penetrant targeted therapies and immunotherapy, and strategies for enhanced delivery of therapy. This review highlights a selection of these approaches.

Original language	English (US)
Pages (from-to)	391-399
Number of pages	9
Journal	Clinical and Experimental Metastasis
Volume	34
Issue number	6-7
DOIs	https://doi.org/10.1007/s10585-017-9861-y
State	Published - Oct 1 2017

Keywords

Blood brain barrier
Brain metastasis
Immunotherapy
Targeted therapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10585-017-9861-y

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title = "Current chemotherapeutic regimens for brain metastases treatment",

abstract = "Brain metastasis is a common complication in advanced systemic cancer, with an increasing incidence. The diagnosis of brain metastasis historically portended a dismal prognosis. The successful development of effective treatments for patients with brain metastasis is complicated by the differences among cancer subtypes, the limited understanding of the underlying pathophysiology of BM, the impact of the blood-brain barrier, and other factors. There is now renewed interest in treating this often devastating complication of cancer, and in understanding the underlying mechanisms of disease in this “sanctuary” site. Promising treatment strategies include brain-penetrant targeted therapies and immunotherapy, and strategies for enhanced delivery of therapy. This review highlights a selection of these approaches.",

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AB - Brain metastasis is a common complication in advanced systemic cancer, with an increasing incidence. The diagnosis of brain metastasis historically portended a dismal prognosis. The successful development of effective treatments for patients with brain metastasis is complicated by the differences among cancer subtypes, the limited understanding of the underlying pathophysiology of BM, the impact of the blood-brain barrier, and other factors. There is now renewed interest in treating this often devastating complication of cancer, and in understanding the underlying mechanisms of disease in this “sanctuary” site. Promising treatment strategies include brain-penetrant targeted therapies and immunotherapy, and strategies for enhanced delivery of therapy. This review highlights a selection of these approaches.

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Current chemotherapeutic regimens for brain metastases treatment

Abstract

Keywords

ASJC Scopus subject areas

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