Abstract
In-transit disease is a unique form of regional lymphatic spread of melanoma that is considered an infrequent event although certain high-risk subgroups have been identified with higher incidence rates. Although this disease entity is associated with a high risk for distant relapse, regionally focused treatment of disease is important due to the high morbidity associated with in-transit disease. Isolated limb perfusion has been a utilized method of regional treatment since the 1950's. The technical aspects, indications, historical results, and toxicity of limb perfusion are reviewed. Finally, perfusion based treatment of in-transit melanoma is an excellent model for studying novel agents and regimens in both the pre-clinical and patient care setting.
Original language | English (US) |
---|---|
Pages (from-to) | 205-217 |
Number of pages | 13 |
Journal | International Journal of Hyperthermia |
Volume | 24 |
Issue number | 3 |
DOIs | |
State | Published - May 2008 |
Keywords
- Limb perfusion
- Melanoma
- Regional chemotherapy
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Cancer Research