Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer

Maria Smolle; Stefan Uranitsch; Armin Gerger; Martin Pichler; Johannes Haybaeck

doi:10.3390/ijms150813993

Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer

Maria Smolle, Stefan Uranitsch, Armin Gerger, Martin Pichler, Johannes Haybaeck

Experimental Therapeutics

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.

Original language	English (US)
Pages (from-to)	13993-14013
Number of pages	21
Journal	International journal of molecular sciences
Volume	15
Issue number	8
DOIs	https://doi.org/10.3390/ijms150813993
State	Published - Aug 12 2014

Keywords

Cancer
Colorectal cancer
LncRNA
Molecular tumor pathogenesis

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms150813993

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title = "Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer",

abstract = "The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.",

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T1 - Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer

AU - Smolle, Maria

AU - Uranitsch, Stefan

AU - Gerger, Armin

AU - Pichler, Martin

AU - Haybaeck, Johannes

PY - 2014/8/12

Y1 - 2014/8/12

N2 - The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.

AB - The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.

KW - Cancer

KW - Colorectal cancer

KW - LncRNA

KW - Molecular tumor pathogenesis

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JO - International journal of molecular sciences

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Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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