Current update on combined hepatocellular-cholangiocarcinoma

Suresh Maximin, Dhakshina Moorthy Ganeshan, Alampady K. Shanbhogue, Manjiri K. Dighe, Matthew M. Yeh, Orpheus Kolokythas, Puneet Bhargava, Neeraj Lalwani

    Research output: Contribution to journalReview article

    28 Scopus citations


    Combined hepatocellular-cholangiocarcinoma is a rare but unique primary hepatic tumor with characteristic histology and tumor biology.Recent development in genetics and molecular biology support the fact that combined hepatocellular-cholangiocarcinoma is closely linked withcholangiocarcinoma, rather than hepatocellular carcinoma. Combined hepatocellular cholangiocarcinoma tends to present with an more aggressive behavior and a poorer prognosis than either hepatocellularcarcinoma or cholangiocarcinoma. An accurate preoperative diagnosis and aggressive treatment planning can play crucial roles in appropriate patientmanagement.

    Original languageEnglish (US)
    Pages (from-to)40-48
    Number of pages9
    JournalEuropean Journal of Radiology Open
    Issue number1
    StatePublished - Jan 1 2014



    • Cholangiocarcinoma
    • Cirrhosis
    • Computed tomography
    • Hepatocellular carcinoma
    • Magnetic resonance imaging

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Maximin, S., Ganeshan, D. M., Shanbhogue, A. K., Dighe, M. K., Yeh, M. M., Kolokythas, O., Bhargava, P., & Lalwani, N. (2014). Current update on combined hepatocellular-cholangiocarcinoma. European Journal of Radiology Open, 1(1), 40-48.