Cutting edge: CD28 controls peripheral homeostasis of CD4 +CD25+ regulatory T cells

Qizhi Tang; Kammi J. Henriksen; Elisa K. Boden; Aaron J. Tooley; Jianqin Ye; Sumit K. Subudhi; Xin X. Zheng; Terry B. Strom; Jeffrey A. Bluestone

doi:10.4049/jimmunol.171.7.3348

Cutting edge: CD28 controls peripheral homeostasis of CD4 ⁺CD25⁺ regulatory T cells

Qizhi Tang, Kammi J. Henriksen, Elisa K. Boden, Aaron J. Tooley, Jianqin Ye, Sumit K. Subudhi, Xin X. Zheng, Terry B. Strom, Jeffrey A. Bluestone

Research output: Contribution to journal › Article › peer-review

575 Scopus citations

Abstract

CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4⁺CD25⁺ regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.

Original language	English (US)
Pages (from-to)	3348-3352
Number of pages	5
Journal	Journal of Immunology
Volume	171
Issue number	7
DOIs	https://doi.org/10.4049/jimmunol.171.7.3348
State	Published - Oct 1 2003
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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abstract = "CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4+CD25+ regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.",

author = "Qizhi Tang and Henriksen, {Kammi J.} and Boden, {Elisa K.} and Tooley, {Aaron J.} and Jianqin Ye and Subudhi, {Sumit K.} and Zheng, {Xin X.} and Strom, {Terry B.} and Bluestone, {Jeffrey A.}",

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doi = "10.4049/jimmunol.171.7.3348",

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AU - Tang, Qizhi

AU - Henriksen, Kammi J.

AU - Boden, Elisa K.

AU - Tooley, Aaron J.

AU - Ye, Jianqin

AU - Subudhi, Sumit K.

AU - Zheng, Xin X.

AU - Strom, Terry B.

AU - Bluestone, Jeffrey A.

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AB - CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4+CD25+ regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.

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Cutting edge: CD28 controls peripheral homeostasis of CD4 ⁺CD25⁺ regulatory T cells

Abstract

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