TY - JOUR
T1 - Cyclin D1 gene polymorphism and susceptibility to lung cancer in a Chinese population
AU - Qiuling, Shi
AU - Yuxin, Zheng
AU - Suhua, Zheng
AU - Cheng, Xiao
AU - Shuguang, Leng
AU - Fengsheng, He
N1 - Funding Information:
The authors thank Dr Qingyi Wei (Department of Epidemiology, M.D. Anderson Cancer Center, TX) for editing the manuscript. This investigation was supported in part by the National Key Basic Research and Development Program (2002CB512903).
PY - 2003/9/1
Y1 - 2003/9/1
N2 - The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showed that the frequencies of the CCND1 AA, GA and GG genotypes were 31.3, 46.7 and 22.0% respectively in cases, and 21.1, 53.0 and 25.9 respectively in controls. Adjusted by age (in years), sex and smoking status, multivariate logistic regression analysis showed that the AA genotype was associated with a significantly increased risk (OR = 1.87, 95% CI 1.01-3.45) for lung cancer. In the stratification analysis, the CCND1 AA variant genotype was associated with increased risk in individuals who were <50 years old (OR = 3.23, 95% CI 1.17-8.96) and males (OR = 2.46, 95% CI 1.18-5.10). According to histological types, there was significantly higher frequency of AA genotype in squamous cell lung cancer than that in controls (OR = 2.92, 95% CI 1.07-8.03). In conclusion, it is suggested that the CCND1 G/A polymorphism is associated with the early onset of lung cancer in men and contributes to susceptibility to lung cancer, especially squamous cell cancer, in this population.
AB - The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showed that the frequencies of the CCND1 AA, GA and GG genotypes were 31.3, 46.7 and 22.0% respectively in cases, and 21.1, 53.0 and 25.9 respectively in controls. Adjusted by age (in years), sex and smoking status, multivariate logistic regression analysis showed that the AA genotype was associated with a significantly increased risk (OR = 1.87, 95% CI 1.01-3.45) for lung cancer. In the stratification analysis, the CCND1 AA variant genotype was associated with increased risk in individuals who were <50 years old (OR = 3.23, 95% CI 1.17-8.96) and males (OR = 2.46, 95% CI 1.18-5.10). According to histological types, there was significantly higher frequency of AA genotype in squamous cell lung cancer than that in controls (OR = 2.92, 95% CI 1.07-8.03). In conclusion, it is suggested that the CCND1 G/A polymorphism is associated with the early onset of lung cancer in men and contributes to susceptibility to lung cancer, especially squamous cell cancer, in this population.
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U2 - 10.1093/carcin/bgg035
DO - 10.1093/carcin/bgg035
M3 - Article
C2 - 12807740
AN - SCOPUS:0141479951
SN - 0143-3334
VL - 24
SP - 1499
EP - 1503
JO - Carcinogenesis
JF - Carcinogenesis
IS - 9
ER -