TY - JOUR
T1 - Cyclin e deregulation is an early event in the development of breast cancer
AU - Shaye, Alexandra
AU - Sahin, Aysegul
AU - Hao, Qiang
AU - Hunt, Kelly
AU - Keyomarsi, Khandan
AU - Bedrosian, Isabelle
N1 - Funding Information:
Acknowledgments The authors wish to thank Robyn Kuhn and Roland L. Bassett Jr. for their assistance with the statistical analysis. Supported by Texas Federation of Business and Professional Women and National Institutes of Health grant CA116199 (SPORE in Breast Cancer).
PY - 2009/6
Y1 - 2009/6
N2 - Cyclin E has been shown to be overexpressed in some human breast cancers, however, data to support deregulation of cyclin E as an early event in human mammary tumor development is lacking. We analyzed surgical specimens from 183 patients with breast carcinomas and evaluated cyclin E expression in areas of invasive carcinoma, adjacent carcinoma in situ (CIS), and non-neoplastic breast parenchyma. Overexpression of cyclin E was seen in one-third of invasive carcinoma samples, one-third of the CIS component and nearly half of the non-neoplastic breast epithelial cells adjacent to carcinoma (44% vs. 33%, P ≤ 0.05). Nuclear labeling for cyclin E was highly concordant between areas of in invasive carcinoma, CIS and non-neoplastic breast epithelial cells from the same patient (P < 0.0001). Localization of cyclin E to the cytoplasm was seen in a small proportion of tumor samples. Our findings suggest that cyclin E deregulation is an early event in the progression from histologically benign mammary epithelial cells to invasive carcinoma and occurs through both overexpression and altered cellular localization.
AB - Cyclin E has been shown to be overexpressed in some human breast cancers, however, data to support deregulation of cyclin E as an early event in human mammary tumor development is lacking. We analyzed surgical specimens from 183 patients with breast carcinomas and evaluated cyclin E expression in areas of invasive carcinoma, adjacent carcinoma in situ (CIS), and non-neoplastic breast parenchyma. Overexpression of cyclin E was seen in one-third of invasive carcinoma samples, one-third of the CIS component and nearly half of the non-neoplastic breast epithelial cells adjacent to carcinoma (44% vs. 33%, P ≤ 0.05). Nuclear labeling for cyclin E was highly concordant between areas of in invasive carcinoma, CIS and non-neoplastic breast epithelial cells from the same patient (P < 0.0001). Localization of cyclin E to the cytoplasm was seen in a small proportion of tumor samples. Our findings suggest that cyclin E deregulation is an early event in the progression from histologically benign mammary epithelial cells to invasive carcinoma and occurs through both overexpression and altered cellular localization.
KW - Breast cancer
KW - Cyclin E
KW - Cytoplasmic localization
KW - Premalignant breast disease
UR - http://www.scopus.com/inward/record.url?scp=67349178622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349178622&partnerID=8YFLogxK
U2 - 10.1007/s10549-008-0266-0
DO - 10.1007/s10549-008-0266-0
M3 - Article
C2 - 19107593
AN - SCOPUS:67349178622
SN - 0167-6806
VL - 115
SP - 651
EP - 659
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 3
ER -