TY - JOUR
T1 - Cytogenetic findings in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
T2 - Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course
AU - Mansoor, Adnan
AU - Medeiros, L. Jeffrey
AU - Weber, Donna M.
AU - Alexanian, Raymond
AU - Hayes, Kimberly
AU - Ones, Dan J.
AU - Lai, Raymond
AU - Glassman, Armand
AU - Bueso-Ramos, Carlos E.
PY - 2001/10
Y1 - 2001/10
N2 - We correlated bone marrow cytogenetic findings with morphologic and immunophenotypic data in 37 patients with lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM). Each LPL/WM case was classified as lymphoplasmacytoid (n = 18), lymphoplasmacytic (n = 10), or polymorphous (n = 9) using the Kiel criteria. Of 12 cases with chromosomal abnormalities, a single numeric abnormality was present in 4 and a complex karyotype in 8. The most common numeric abnormalities were +5 and -8 in 3 cases each; the most common structural abnormality was del(6q) in 6 cases. Cytogenetic abnormalities were significantly less common in the lymphoplasmacytic and lymphoplasmacytoid groups (5/28 [18%]) compared with the polymorphous group (7/9 [78%]). Clinical follow-up was available for 28 patients for a median of 36 months. Six (67%) of 9 patients with aneuploid tumors, including 4 with polymorphous subtype, subsequently had clinical progression or developed high-grade lymphoma. In contrast, 4 (21%) of 19 patients with diploid tumors, including 1 of polymorphous type, developed clinical progression or high-grade lymphoma. We conclude that abnormal cytogenetic findings in LPL/WM correlate with the polymorphous subtype and poor prognosis.
AB - We correlated bone marrow cytogenetic findings with morphologic and immunophenotypic data in 37 patients with lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM). Each LPL/WM case was classified as lymphoplasmacytoid (n = 18), lymphoplasmacytic (n = 10), or polymorphous (n = 9) using the Kiel criteria. Of 12 cases with chromosomal abnormalities, a single numeric abnormality was present in 4 and a complex karyotype in 8. The most common numeric abnormalities were +5 and -8 in 3 cases each; the most common structural abnormality was del(6q) in 6 cases. Cytogenetic abnormalities were significantly less common in the lymphoplasmacytic and lymphoplasmacytoid groups (5/28 [18%]) compared with the polymorphous group (7/9 [78%]). Clinical follow-up was available for 28 patients for a median of 36 months. Six (67%) of 9 patients with aneuploid tumors, including 4 with polymorphous subtype, subsequently had clinical progression or developed high-grade lymphoma. In contrast, 4 (21%) of 19 patients with diploid tumors, including 1 of polymorphous type, developed clinical progression or high-grade lymphoma. We conclude that abnormal cytogenetic findings in LPL/WM correlate with the polymorphous subtype and poor prognosis.
KW - Chromosomal abnormalities
KW - Cytogenetics
KW - Lymphoplasmacytic lymphoma
KW - Waldenström macroglobulinemia
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U2 - 10.1309/6U88-357U-UKJ5-YPT3
DO - 10.1309/6U88-357U-UKJ5-YPT3
M3 - Article
C2 - 11601139
AN - SCOPUS:0035736119
SN - 0002-9173
VL - 116
SP - 543
EP - 549
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 4
ER -