TY - JOUR
T1 - Cytokine-induced sickness behaviour
T2 - Mechanisms and implications
AU - Konsman, Jan Pieter
AU - Parnet, Patricia
AU - Dantzer, Robert
PY - 2002/3/1
Y1 - 2002/3/1
N2 - Sickness behaviour represents the expression of the adaptive reorganization of the priorities of the host during an infectious episode. This process is triggered by pro-inflammatory cytokines produced by peripheral phagocytic cells in contact with invading micro-organisms. The peripheral immune message is relayed to the brain via a fast neural pathway and a slower humoral pathway, resulting in the expression of pro-inflammatory cytokines in macrophage-like cells and microglia in the brain. The cellular and molecular components of this previously unsuspected system are being progressively identified. These advances are opening new avenues for understanding brain disorders, including depression.
AB - Sickness behaviour represents the expression of the adaptive reorganization of the priorities of the host during an infectious episode. This process is triggered by pro-inflammatory cytokines produced by peripheral phagocytic cells in contact with invading micro-organisms. The peripheral immune message is relayed to the brain via a fast neural pathway and a slower humoral pathway, resulting in the expression of pro-inflammatory cytokines in macrophage-like cells and microglia in the brain. The cellular and molecular components of this previously unsuspected system are being progressively identified. These advances are opening new avenues for understanding brain disorders, including depression.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036498510&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(00)02088-9
DO - 10.1016/S0166-2236(00)02088-9
M3 - Review article
C2 - 11852148
AN - SCOPUS:0036498510
SN - 0166-2236
VL - 25
SP - 154
EP - 159
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 3
ER -