TY - JOUR
T1 - Cytology versus HPV testing for the detection of high-grade cervical lesions in women found positive on visual inspection in Mumbai, India
AU - Pimple, Sharmila
AU - Muwonge, Richard
AU - Amin, Geetanjali
AU - Goswami, Smriti
AU - Sankaranarayanan, Rengaswamy
AU - Shastri, Surendra S.
N1 - Funding Information:
This study was supported by the Bill & Melinda Gates Foundation through the Alliance for Cervical Cancer Prevention.
PY - 2010/3
Y1 - 2010/3
N2 - Objective: To compare the utility of cytology and HPV testing in women from Mumbai, India, suspected of having cervical intraepithelial neoplasia (CIN) on visual inspection with acetic acid (VIA), Lugol's iodine (VILI), or both. Method: The sensitivity, specificity, and predictive values of these tests for the detection of CIN 2 and/or 3 were evaluated in this cross-sectional study with 756 women suspected of having CIN on visual inspection. Results: There were 25 women with CIN 2, 20 with CIN 3, and 21 with invasive cancer. The sensitivity to detect CIN 3 lesions was 85.0% (95% CI, 62.1-96.8) and 70.0% (95% CI, 45.7-88.1) for cytology testing at the ASCUS and LSIL thresholds, respectively, and it was 89.5% (95% CI, 66.9-98.7) for HPV testing. The specificity to detect CIN 3 lesions was 94.5% (95% CI, 92.5-96.1) and 96.1% (95% CI, 94.4-97.5) for cytology testing at the ASCUS and LSIL thresholds, and it was 91.1% (95% CI, 88.5-93.2) for HPV testing. Conclusion: Cytology and HPV testing were both found to be accurate triaging methods for women suspected of having CIN on visual inspection, especially for those with CIN 3 lesions.
AB - Objective: To compare the utility of cytology and HPV testing in women from Mumbai, India, suspected of having cervical intraepithelial neoplasia (CIN) on visual inspection with acetic acid (VIA), Lugol's iodine (VILI), or both. Method: The sensitivity, specificity, and predictive values of these tests for the detection of CIN 2 and/or 3 were evaluated in this cross-sectional study with 756 women suspected of having CIN on visual inspection. Results: There were 25 women with CIN 2, 20 with CIN 3, and 21 with invasive cancer. The sensitivity to detect CIN 3 lesions was 85.0% (95% CI, 62.1-96.8) and 70.0% (95% CI, 45.7-88.1) for cytology testing at the ASCUS and LSIL thresholds, respectively, and it was 89.5% (95% CI, 66.9-98.7) for HPV testing. The specificity to detect CIN 3 lesions was 94.5% (95% CI, 92.5-96.1) and 96.1% (95% CI, 94.4-97.5) for cytology testing at the ASCUS and LSIL thresholds, and it was 91.1% (95% CI, 88.5-93.2) for HPV testing. Conclusion: Cytology and HPV testing were both found to be accurate triaging methods for women suspected of having CIN on visual inspection, especially for those with CIN 3 lesions.
KW - Cervical intraepithelial neoplasia
KW - Cytology
KW - Early detection
KW - HPV testing
KW - Screening
KW - Visual inspection
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U2 - 10.1016/j.ijgo.2009.10.005
DO - 10.1016/j.ijgo.2009.10.005
M3 - Article
C2 - 19945105
AN - SCOPUS:76049106305
SN - 0020-7292
VL - 108
SP - 236
EP - 239
JO - International Journal of Gynecology and Obstetrics
JF - International Journal of Gynecology and Obstetrics
IS - 3
ER -