Cytotoxic and targeted systemic therapy in patients with advanced cutaneous squamous cell carcinoma in the head and neck

Samantha Tam; Mona Gajera; Xiaoning Luo; Bonnie S. Glisson; Renata Ferrarotto; Faye M. Johnson; Frank E. Mott; Maura L. Gillison; Charles Lu; Xiuning Le; George R. Blumenschein; Michael K. Wong; David I. Rosenthal; Priyadharsini Nagarajan; Adel K. El-Naggar; Michael R. Midgen; Randal S. Weber; Jeffrey N. Myers; Neil D. Gross

doi:10.1002/hed.26626

Cytotoxic and targeted systemic therapy in patients with advanced cutaneous squamous cell carcinoma in the head and neck

Samantha Tam, Mona Gajera, Xiaoning Luo, Bonnie S. Glisson, Renata Ferrarotto, Faye M. Johnson, Frank E. Mott, Maura L. Gillison, Charles Lu, Xiuning Le, George R. Blumenschein, Michael K. Wong, David I. Rosenthal, Priyadharsini Nagarajan, Adel K. El-Naggar, Michael R. Midgen, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: The outcomes of patients treated with cytotoxic or targeted systemic therapy is not well defined for cutaneous squamous cell carcinoma of the head and neck (cSCCHN). Methods: Patients with cSCCHN treated with cytotoxic or targeted systemic therapy were included. Patients were divided into two groups based on the presence of distant metastasis (M1 vs. M0) at presentation. A proportional hazards model was used to assess for independent predictors of overall survival. Results: Of 129 patients with cSCCHN, 20 (16%) were M1 and 109 (84%) were M0. Independent predictors of improved survival were M0 status, treatment of locally advanced disease with radiotherapy, and lower Eastern Cooperative Oncology Group (ECOG) score. Conclusions: Survival was worse in M1 patients treated with cytotoxic or targeted systemic therapy and poor baseline performance status but improved in those receiving radiotherapy. These data can serve as historical controls for future systemic therapy trials, including immunotherapy.

Original language	English (US)
Pages (from-to)	1592-1603
Number of pages	12
Journal	Head and Neck
Volume	43
Issue number	5
DOIs	https://doi.org/10.1002/hed.26626
State	Published - May 2021

Keywords

chemotherapy
head and neck neoplasms
skin neoplasms
squamous cell carcinoma
systemic therapy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26626

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Tam, S., Gajera, M., Luo, X., Glisson, B. S., Ferrarotto, R., Johnson, F. M., Mott, F. E., Gillison, M. L., Lu, C., Le, X., Blumenschein, G. R., Wong, M. K., Rosenthal, D. I., Nagarajan, P., El-Naggar, A. K., Midgen, M. R., Weber, R. S., Myers, J. N., & Gross, N. D. (2021). Cytotoxic and targeted systemic therapy in patients with advanced cutaneous squamous cell carcinoma in the head and neck. Head and Neck, 43(5), 1592-1603. https://doi.org/10.1002/hed.26626

Tam, S, Gajera, M, Luo, X, Glisson, BS, Ferrarotto, R , Johnson, FM, Mott, FE, Gillison, ML , Lu, C , Le, X , Blumenschein, GR , Wong, MK , Rosenthal, DI , Nagarajan, P , El-Naggar, AK, Midgen, MR, Weber, RS, Myers, JN & Gross, ND 2021, 'Cytotoxic and targeted systemic therapy in patients with advanced cutaneous squamous cell carcinoma in the head and neck', Head and Neck, vol. 43, no. 5, pp. 1592-1603. https://doi.org/10.1002/hed.26626

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title = "Cytotoxic and targeted systemic therapy in patients with advanced cutaneous squamous cell carcinoma in the head and neck",

abstract = "Background: The outcomes of patients treated with cytotoxic or targeted systemic therapy is not well defined for cutaneous squamous cell carcinoma of the head and neck (cSCCHN). Methods: Patients with cSCCHN treated with cytotoxic or targeted systemic therapy were included. Patients were divided into two groups based on the presence of distant metastasis (M1 vs. M0) at presentation. A proportional hazards model was used to assess for independent predictors of overall survival. Results: Of 129 patients with cSCCHN, 20 (16%) were M1 and 109 (84%) were M0. Independent predictors of improved survival were M0 status, treatment of locally advanced disease with radiotherapy, and lower Eastern Cooperative Oncology Group (ECOG) score. Conclusions: Survival was worse in M1 patients treated with cytotoxic or targeted systemic therapy and poor baseline performance status but improved in those receiving radiotherapy. These data can serve as historical controls for future systemic therapy trials, including immunotherapy.",

keywords = "chemotherapy, head and neck neoplasms, skin neoplasms, squamous cell carcinoma, systemic therapy",

author = "Samantha Tam and Mona Gajera and Xiaoning Luo and Glisson, {Bonnie S.} and Renata Ferrarotto and Johnson, {Faye M.} and Mott, {Frank E.} and Gillison, {Maura L.} and Charles Lu and Xiuning Le and Blumenschein, {George R.} and Wong, {Michael K.} and Rosenthal, {David I.} and Priyadharsini Nagarajan and El-Naggar, {Adel K.} and Midgen, {Michael R.} and Weber, {Randal S.} and Myers, {Jeffrey N.} and Gross, {Neil D.}",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",

year = "2021",

month = may,

doi = "10.1002/hed.26626",

language = "English (US)",

volume = "43",

pages = "1592--1603",

journal = "Head and Neck",

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TY - JOUR

T1 - Cytotoxic and targeted systemic therapy in patients with advanced cutaneous squamous cell carcinoma in the head and neck

AU - Tam, Samantha

AU - Gajera, Mona

AU - Luo, Xiaoning

AU - Glisson, Bonnie S.

AU - Ferrarotto, Renata

AU - Johnson, Faye M.

AU - Mott, Frank E.

AU - Gillison, Maura L.

AU - Lu, Charles

AU - Le, Xiuning

AU - Blumenschein, George R.

AU - Wong, Michael K.

AU - Rosenthal, David I.

AU - Nagarajan, Priyadharsini

AU - El-Naggar, Adel K.

AU - Midgen, Michael R.

AU - Weber, Randal S.

AU - Myers, Jeffrey N.

AU - Gross, Neil D.

PY - 2021/5

Y1 - 2021/5

N2 - Background: The outcomes of patients treated with cytotoxic or targeted systemic therapy is not well defined for cutaneous squamous cell carcinoma of the head and neck (cSCCHN). Methods: Patients with cSCCHN treated with cytotoxic or targeted systemic therapy were included. Patients were divided into two groups based on the presence of distant metastasis (M1 vs. M0) at presentation. A proportional hazards model was used to assess for independent predictors of overall survival. Results: Of 129 patients with cSCCHN, 20 (16%) were M1 and 109 (84%) were M0. Independent predictors of improved survival were M0 status, treatment of locally advanced disease with radiotherapy, and lower Eastern Cooperative Oncology Group (ECOG) score. Conclusions: Survival was worse in M1 patients treated with cytotoxic or targeted systemic therapy and poor baseline performance status but improved in those receiving radiotherapy. These data can serve as historical controls for future systemic therapy trials, including immunotherapy.

AB - Background: The outcomes of patients treated with cytotoxic or targeted systemic therapy is not well defined for cutaneous squamous cell carcinoma of the head and neck (cSCCHN). Methods: Patients with cSCCHN treated with cytotoxic or targeted systemic therapy were included. Patients were divided into two groups based on the presence of distant metastasis (M1 vs. M0) at presentation. A proportional hazards model was used to assess for independent predictors of overall survival. Results: Of 129 patients with cSCCHN, 20 (16%) were M1 and 109 (84%) were M0. Independent predictors of improved survival were M0 status, treatment of locally advanced disease with radiotherapy, and lower Eastern Cooperative Oncology Group (ECOG) score. Conclusions: Survival was worse in M1 patients treated with cytotoxic or targeted systemic therapy and poor baseline performance status but improved in those receiving radiotherapy. These data can serve as historical controls for future systemic therapy trials, including immunotherapy.

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KW - head and neck neoplasms

KW - skin neoplasms

KW - squamous cell carcinoma

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Cytotoxic and targeted systemic therapy in patients with advanced cutaneous squamous cell carcinoma in the head and neck

Abstract

Keywords

ASJC Scopus subject areas

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