Daily Bone Alignment With Limited Repeat CT Correction Rivals Daily Ultrasound Alignment for Prostate Radiotherapy

Jennifer C. O'Daniel; Lei Dong; Lifei Zhang; He Wang; Susan L. Tucker; Rajat J. Kudchadker; Andrew K. Lee; Rex Cheung; James D. Cox; Deborah A. Kuban; Radhe Mohan

doi:10.1016/j.ijrobp.2008.01.026

Daily Bone Alignment With Limited Repeat CT Correction Rivals Daily Ultrasound Alignment for Prostate Radiotherapy

Jennifer C. O'Daniel, Lei Dong, Lifei Zhang, He Wang, Susan L. Tucker, Rajat J. Kudchadker, Andrew K. Lee, Rex Cheung, James D. Cox, Deborah A. Kuban, Radhe Mohan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose: To compare the effectiveness of daily ultrasound (US)- and computed tomography (CT)-guided alignments with an off-line correction protocol using daily bone alignment plus a correction factor for systematic internal prostate displacement (CF_ID). Methods and Materials: Ten prostate cancer patients underwent CT scans three times weekly using an integrated CT-linear accelerator system, followed by alignment using US for daily radiotherapy. Intensity-modulated radiotherapy plans were designed with our current clinical margins. The treatment plan was copied onto the repeat CT images and aligned using several methods: (1) bone alignment plus CF_ID after three off-line CT scans (bone+3CT), (2) bone alignment plus CF_ID after six off-line CT scans (bone+6CT), (3) US alignment, and (4) CT alignment. The accuracy of the repeated US and CT measurements to determine the CF_ID was compared. The target dosimetric effect was quantified. Results: The CF_ID for internal systematic prostate displacements was more accurately measured with limited repeat CT scans than with US (residual error, 0.0 ± 0.7 mm vs. 2.0 ± 3.2 mm). Bone+3CT, bone+6CT, and US provided equivalent prostate and seminal vesicle dose coverage, but bone+3CT and bone+6CT produced more precise daily alignments. Daily CT alignment provided the greatest target dose coverage. Conclusion: Daily bone alignment plus CF_ID for internal systematic prostate displacement provided better daily alignment precision and equivalent dose coverage compared with daily US alignment. The CF_ID should be based on at least three repeat CT scans, which could be collected before the start of treatment or during the first 3 treatment days. Daily bone alignment plus CF_ID provides another option for accurate prostate cancer patient positioning.

Original language	English (US)
Pages (from-to)	274-280
Number of pages	7
Journal	International Journal of Radiation Oncology Biology Physics
Volume	71
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2008.01.026
State	Published - May 1 2008

Keywords

CT-guided radiotherapy
Image-guided radiotherapy
No-action-level protocol
Prostate cancer
Setup uncertainties

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

MD Anderson CCSG core facilities

Bioinformatics Shared Resource

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10.1016/j.ijrobp.2008.01.026

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O'Daniel, J. C., Dong, L., Zhang, L., Wang, H., Tucker, S. L., Kudchadker, R. J., Lee, A. K., Cheung, R., Cox, J. D., Kuban, D. A., & Mohan, R. (2008). Daily Bone Alignment With Limited Repeat CT Correction Rivals Daily Ultrasound Alignment for Prostate Radiotherapy. International Journal of Radiation Oncology Biology Physics, 71(1), 274-280. https://doi.org/10.1016/j.ijrobp.2008.01.026

O'Daniel, JC, Dong, L, Zhang, L, Wang, H, Tucker, SL, Kudchadker, RJ, Lee, AK, Cheung, R, Cox, JD, Kuban, DA & Mohan, R 2008, 'Daily Bone Alignment With Limited Repeat CT Correction Rivals Daily Ultrasound Alignment for Prostate Radiotherapy', International Journal of Radiation Oncology Biology Physics, vol. 71, no. 1, pp. 274-280. https://doi.org/10.1016/j.ijrobp.2008.01.026

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title = "Daily Bone Alignment With Limited Repeat CT Correction Rivals Daily Ultrasound Alignment for Prostate Radiotherapy",

abstract = "Purpose: To compare the effectiveness of daily ultrasound (US)- and computed tomography (CT)-guided alignments with an off-line correction protocol using daily bone alignment plus a correction factor for systematic internal prostate displacement (CFID). Methods and Materials: Ten prostate cancer patients underwent CT scans three times weekly using an integrated CT-linear accelerator system, followed by alignment using US for daily radiotherapy. Intensity-modulated radiotherapy plans were designed with our current clinical margins. The treatment plan was copied onto the repeat CT images and aligned using several methods: (1) bone alignment plus CFID after three off-line CT scans (bone+3CT), (2) bone alignment plus CFID after six off-line CT scans (bone+6CT), (3) US alignment, and (4) CT alignment. The accuracy of the repeated US and CT measurements to determine the CFID was compared. The target dosimetric effect was quantified. Results: The CFID for internal systematic prostate displacements was more accurately measured with limited repeat CT scans than with US (residual error, 0.0 ± 0.7 mm vs. 2.0 ± 3.2 mm). Bone+3CT, bone+6CT, and US provided equivalent prostate and seminal vesicle dose coverage, but bone+3CT and bone+6CT produced more precise daily alignments. Daily CT alignment provided the greatest target dose coverage. Conclusion: Daily bone alignment plus CFID for internal systematic prostate displacement provided better daily alignment precision and equivalent dose coverage compared with daily US alignment. The CFID should be based on at least three repeat CT scans, which could be collected before the start of treatment or during the first 3 treatment days. Daily bone alignment plus CFID provides another option for accurate prostate cancer patient positioning.",

keywords = "CT-guided radiotherapy, Image-guided radiotherapy, No-action-level protocol, Prostate cancer, Setup uncertainties",

author = "O'Daniel, {Jennifer C.} and Lei Dong and Lifei Zhang and He Wang and Tucker, {Susan L.} and Kudchadker, {Rajat J.} and Lee, {Andrew K.} and Rex Cheung and Cox, {James D.} and Kuban, {Deborah A.} and Radhe Mohan",

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doi = "10.1016/j.ijrobp.2008.01.026",

language = "English (US)",

volume = "71",

pages = "274--280",

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TY - JOUR

T1 - Daily Bone Alignment With Limited Repeat CT Correction Rivals Daily Ultrasound Alignment for Prostate Radiotherapy

AU - O'Daniel, Jennifer C.

AU - Dong, Lei

AU - Zhang, Lifei

AU - Wang, He

AU - Tucker, Susan L.

AU - Kudchadker, Rajat J.

AU - Lee, Andrew K.

AU - Cheung, Rex

AU - Cox, James D.

AU - Kuban, Deborah A.

AU - Mohan, Radhe

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Purpose: To compare the effectiveness of daily ultrasound (US)- and computed tomography (CT)-guided alignments with an off-line correction protocol using daily bone alignment plus a correction factor for systematic internal prostate displacement (CFID). Methods and Materials: Ten prostate cancer patients underwent CT scans three times weekly using an integrated CT-linear accelerator system, followed by alignment using US for daily radiotherapy. Intensity-modulated radiotherapy plans were designed with our current clinical margins. The treatment plan was copied onto the repeat CT images and aligned using several methods: (1) bone alignment plus CFID after three off-line CT scans (bone+3CT), (2) bone alignment plus CFID after six off-line CT scans (bone+6CT), (3) US alignment, and (4) CT alignment. The accuracy of the repeated US and CT measurements to determine the CFID was compared. The target dosimetric effect was quantified. Results: The CFID for internal systematic prostate displacements was more accurately measured with limited repeat CT scans than with US (residual error, 0.0 ± 0.7 mm vs. 2.0 ± 3.2 mm). Bone+3CT, bone+6CT, and US provided equivalent prostate and seminal vesicle dose coverage, but bone+3CT and bone+6CT produced more precise daily alignments. Daily CT alignment provided the greatest target dose coverage. Conclusion: Daily bone alignment plus CFID for internal systematic prostate displacement provided better daily alignment precision and equivalent dose coverage compared with daily US alignment. The CFID should be based on at least three repeat CT scans, which could be collected before the start of treatment or during the first 3 treatment days. Daily bone alignment plus CFID provides another option for accurate prostate cancer patient positioning.

AB - Purpose: To compare the effectiveness of daily ultrasound (US)- and computed tomography (CT)-guided alignments with an off-line correction protocol using daily bone alignment plus a correction factor for systematic internal prostate displacement (CFID). Methods and Materials: Ten prostate cancer patients underwent CT scans three times weekly using an integrated CT-linear accelerator system, followed by alignment using US for daily radiotherapy. Intensity-modulated radiotherapy plans were designed with our current clinical margins. The treatment plan was copied onto the repeat CT images and aligned using several methods: (1) bone alignment plus CFID after three off-line CT scans (bone+3CT), (2) bone alignment plus CFID after six off-line CT scans (bone+6CT), (3) US alignment, and (4) CT alignment. The accuracy of the repeated US and CT measurements to determine the CFID was compared. The target dosimetric effect was quantified. Results: The CFID for internal systematic prostate displacements was more accurately measured with limited repeat CT scans than with US (residual error, 0.0 ± 0.7 mm vs. 2.0 ± 3.2 mm). Bone+3CT, bone+6CT, and US provided equivalent prostate and seminal vesicle dose coverage, but bone+3CT and bone+6CT produced more precise daily alignments. Daily CT alignment provided the greatest target dose coverage. Conclusion: Daily bone alignment plus CFID for internal systematic prostate displacement provided better daily alignment precision and equivalent dose coverage compared with daily US alignment. The CFID should be based on at least three repeat CT scans, which could be collected before the start of treatment or during the first 3 treatment days. Daily bone alignment plus CFID provides another option for accurate prostate cancer patient positioning.

KW - CT-guided radiotherapy

KW - Image-guided radiotherapy

KW - No-action-level protocol

KW - Prostate cancer

KW - Setup uncertainties

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JO - International Journal of Radiation Oncology Biology Physics

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ER -

Daily Bone Alignment With Limited Repeat CT Correction Rivals Daily Ultrasound Alignment for Prostate Radiotherapy

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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