Abstract
Imatinib is currently regarded as the best initial treatment for patients with chronic myeloid leukemia (CML). However, a significant proportion of patients who relapse, fail to respond, or develop intolerance might benefit from the use of second-generation tyrosine kinase inhibitors. In this review, we report the 2-year results in 8 clinical trials involving more than 2000 patients treated with dasatinib (phases I-III). Patients with CML who had failed to respond or were intolerant to imatinib were enrolled in a phase I trial. The positive results emanating from this study led to a series of 5 phase II trials known as START (SRC/ABL tyrosine kinase inhibition activity: research trials of dasatinib). In addition, 2 phase III dose-optimization trials have now been completed. These trials demonstrate that dasatinib offers clinical benefit to patients resistant or intolerant to imatinib, with a well-described and manageable adverse event profile.
Original language | English (US) |
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Pages (from-to) | 417-424 |
Number of pages | 8 |
Journal | Clinical Lymphoma and Myeloma |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1 2009 |
Keywords
- BCR-ABL
- Imatinib intolerance
- Imatinib resistance
- Tyrosine kinase inhibitors
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research