DDT supports the growth of an estrogen-responsive tumor. Mammary tumor growth; pesticides

Alice K. Robison; David A. Sirbasku; George M. Stancel

doi:10.1016/0378-4274(85)90127-4

DDT supports the growth of an estrogen-responsive tumor. Mammary tumor growth; pesticides

Alice K. Robison, David A. Sirbasku, George M. Stancel

Gynecological Oncology & Reproductive Medicine

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

MT2 cells, a clonal cell line of MTW9/PL cells originally obtained from a mammary adenocarcinoma, form estrogen-responsive tumors in Wistar-Furth rats. o,p'-DDT supports MT2 tumor growth at a rate similar to 17β-estradiol. This effect of o,p'-DDT is dose-dependent and specific, since the DDT congener p,p'-DDD, which does not bind to tumor estrogen receptors, does not support tumor growth. This is the first demonstration that DDT can support the growth of an estrogen-responsive tumor.

Original language	English (US)
Pages (from-to)	109-113
Number of pages	5
Journal	Toxicology Letters
Volume	27
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-4274(85)90127-4
State	Published - Sep 1985

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(85)90127-4

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title = "DDT supports the growth of an estrogen-responsive tumor. Mammary tumor growth; pesticides",

abstract = "MT2 cells, a clonal cell line of MTW9/PL cells originally obtained from a mammary adenocarcinoma, form estrogen-responsive tumors in Wistar-Furth rats. o,p'-DDT supports MT2 tumor growth at a rate similar to 17β-estradiol. This effect of o,p'-DDT is dose-dependent and specific, since the DDT congener p,p'-DDD, which does not bind to tumor estrogen receptors, does not support tumor growth. This is the first demonstration that DDT can support the growth of an estrogen-responsive tumor.",

author = "Robison, {Alice K.} and Sirbasku, {David A.} and Stancel, {George M.}",

note = "Funding Information: This work was supported by NIH grants HD-08615 and CA-26617, and American Cancer Society Grant BC-225. D.A.S. is the recipient of an A.S.C. Faculty Research Award (FRA-212). A.K.R. was the recipient of an NIEHS Traineeship (ES-07090).",

year = "1985",

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doi = "10.1016/0378-4274(85)90127-4",

language = "English (US)",

volume = "27",

pages = "109--113",

journal = "Toxicology Letters",

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TY - JOUR

T1 - DDT supports the growth of an estrogen-responsive tumor. Mammary tumor growth; pesticides

AU - Robison, Alice K.

AU - Sirbasku, David A.

AU - Stancel, George M.

N1 - Funding Information: This work was supported by NIH grants HD-08615 and CA-26617, and American Cancer Society Grant BC-225. D.A.S. is the recipient of an A.S.C. Faculty Research Award (FRA-212). A.K.R. was the recipient of an NIEHS Traineeship (ES-07090).

PY - 1985/9

Y1 - 1985/9

N2 - MT2 cells, a clonal cell line of MTW9/PL cells originally obtained from a mammary adenocarcinoma, form estrogen-responsive tumors in Wistar-Furth rats. o,p'-DDT supports MT2 tumor growth at a rate similar to 17β-estradiol. This effect of o,p'-DDT is dose-dependent and specific, since the DDT congener p,p'-DDD, which does not bind to tumor estrogen receptors, does not support tumor growth. This is the first demonstration that DDT can support the growth of an estrogen-responsive tumor.

AB - MT2 cells, a clonal cell line of MTW9/PL cells originally obtained from a mammary adenocarcinoma, form estrogen-responsive tumors in Wistar-Furth rats. o,p'-DDT supports MT2 tumor growth at a rate similar to 17β-estradiol. This effect of o,p'-DDT is dose-dependent and specific, since the DDT congener p,p'-DDD, which does not bind to tumor estrogen receptors, does not support tumor growth. This is the first demonstration that DDT can support the growth of an estrogen-responsive tumor.

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DDT supports the growth of an estrogen-responsive tumor. Mammary tumor growth; pesticides

Abstract

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