TY - JOUR
T1 - Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease
AU - Zong, Yuru
AU - Wang, Xuliang
AU - Cui, Bing
AU - Xiong, Xiaowei
AU - Wu, Andrew
AU - Lin, Chunru
AU - Zhang, Yaohua
N1 - Funding Information:
This work was supported by the Young Scientists Fund of the National Natural Science Foundation of China (China, NSFC , 82101948 ) and Natural Science Foundation of Shandong Province (China, ZR2021QH070 ) to Y. Zhang and a Faculty Scholar Award and bridge funding from The University of Texas, MD Anderson Cancer Center (United States) to C. Lin.
Publisher Copyright:
© 2023 The Authors
PY - 2023/6/7
Y1 - 2023/6/7
N2 - Non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are being studied extensively in a variety of fields. Their roles in metabolism have received increasing attention in recent years but are not yet clear. The regulation of glucose, fatty acid, and amino acid metabolism is an imperative physiological process that occurs in living organisms and takes part in cancer and cardiovascular diseases. Here, we summarize the important roles played by non-coding RNAs in glucose metabolism, fatty acid metabolism, and amino acid metabolism, as well as the mechanisms involved. We also summarize the therapeutic advances for non-coding RNAs in diseases such as obesity, cardiovascular disease, and some metabolic diseases. Overall, non-coding RNAs are indispensable factors in metabolism and have a significant role in the three major metabolisms, which may be exploited as therapeutic targets in the future.
AB - Non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are being studied extensively in a variety of fields. Their roles in metabolism have received increasing attention in recent years but are not yet clear. The regulation of glucose, fatty acid, and amino acid metabolism is an imperative physiological process that occurs in living organisms and takes part in cancer and cardiovascular diseases. Here, we summarize the important roles played by non-coding RNAs in glucose metabolism, fatty acid metabolism, and amino acid metabolism, as well as the mechanisms involved. We also summarize the therapeutic advances for non-coding RNAs in diseases such as obesity, cardiovascular disease, and some metabolic diseases. Overall, non-coding RNAs are indispensable factors in metabolism and have a significant role in the three major metabolisms, which may be exploited as therapeutic targets in the future.
KW - amino acid metabolism
KW - fatty acid metabolism
KW - glucose metabolism
KW - metabolic pathways
KW - non-coding RNA
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U2 - 10.1016/j.ymthe.2023.04.012
DO - 10.1016/j.ymthe.2023.04.012
M3 - Review article
C2 - 37113055
AN - SCOPUS:85159147475
SN - 1525-0016
VL - 31
SP - 1562
EP - 1576
JO - Molecular Therapy
JF - Molecular Therapy
IS - 6
ER -