Decreased incidence of febrile episodes with antibiotic prophylaxis in the treatment of decitabine for myelodysplastic syndrome

Je Hwan Lee; Kyoo Hyung Lee; Jung Hee Lee; Dae Young Kim; Sung Han Kim; Sung Nam Lim; Sung Doo Kim; Yunsuk Choi; Sang Min Lee; Won Sik Lee; Moon Young Choi; Young Don Joo

doi:10.1016/j.leukres.2010.07.006

Decreased incidence of febrile episodes with antibiotic prophylaxis in the treatment of decitabine for myelodysplastic syndrome

Je Hwan Lee, Kyoo Hyung Lee, Jung Hee Lee, Dae Young Kim, Sung Han Kim, Sung Nam Lim, Sung Doo Kim, Yunsuk Choi, Sang Min Lee, Won Sik Lee, Moon Young Choi, Young Don Joo

Lymphoma-Myeloma

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We analyzed the role of antibiotic prophylaxis during decitabine treatment for MDS. The primary endpoint was the incidence of febrile episodes. The total number of decitabine cycles given to 28 patients was 131, and febrile episodes occurred in 15 cycles (11.5%). Antibiotic prophylaxis was orally administered in 95 cycles (72.5%). Febrile episodes were significantly less frequent among patients who received antibiotic prophylaxis (7.4%) than in those without prophylaxis (22.2%) (P= 0.017). In conclusion, antibiotic prophylaxis reduced the incidence of febrile episodes in patients who received decitabine treatment for MDS, especially at earlier cycles and in the presence of severe cytopenia.

Original language	English (US)
Pages (from-to)	499-503
Number of pages	5
Journal	Leukemia Research
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/j.leukres.2010.07.006
State	Published - Apr 2011

Keywords

Antibiotic prophylaxis
Cytopenia
Decitabine
Febrile episode
Myelodysplastic syndrome

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2010.07.006

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title = "Decreased incidence of febrile episodes with antibiotic prophylaxis in the treatment of decitabine for myelodysplastic syndrome",

abstract = "We analyzed the role of antibiotic prophylaxis during decitabine treatment for MDS. The primary endpoint was the incidence of febrile episodes. The total number of decitabine cycles given to 28 patients was 131, and febrile episodes occurred in 15 cycles (11.5%). Antibiotic prophylaxis was orally administered in 95 cycles (72.5%). Febrile episodes were significantly less frequent among patients who received antibiotic prophylaxis (7.4%) than in those without prophylaxis (22.2%) (P= 0.017). In conclusion, antibiotic prophylaxis reduced the incidence of febrile episodes in patients who received decitabine treatment for MDS, especially at earlier cycles and in the presence of severe cytopenia.",

keywords = "Antibiotic prophylaxis, Cytopenia, Decitabine, Febrile episode, Myelodysplastic syndrome",

author = "Lee, {Je Hwan} and Lee, {Kyoo Hyung} and Lee, {Jung Hee} and Kim, {Dae Young} and Kim, {Sung Han} and Lim, {Sung Nam} and Kim, {Sung Doo} and Yunsuk Choi and Lee, {Sang Min} and Lee, {Won Sik} and Choi, {Moon Young} and Joo, {Young Don}",

year = "2011",

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doi = "10.1016/j.leukres.2010.07.006",

language = "English (US)",

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AU - Lee, Je Hwan

AU - Lee, Kyoo Hyung

AU - Lee, Jung Hee

AU - Kim, Dae Young

AU - Kim, Sung Han

AU - Lim, Sung Nam

AU - Kim, Sung Doo

AU - Choi, Yunsuk

AU - Lee, Sang Min

AU - Lee, Won Sik

AU - Choi, Moon Young

AU - Joo, Young Don

PY - 2011/4

Y1 - 2011/4

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AB - We analyzed the role of antibiotic prophylaxis during decitabine treatment for MDS. The primary endpoint was the incidence of febrile episodes. The total number of decitabine cycles given to 28 patients was 131, and febrile episodes occurred in 15 cycles (11.5%). Antibiotic prophylaxis was orally administered in 95 cycles (72.5%). Febrile episodes were significantly less frequent among patients who received antibiotic prophylaxis (7.4%) than in those without prophylaxis (22.2%) (P= 0.017). In conclusion, antibiotic prophylaxis reduced the incidence of febrile episodes in patients who received decitabine treatment for MDS, especially at earlier cycles and in the presence of severe cytopenia.

KW - Antibiotic prophylaxis

KW - Cytopenia

KW - Decitabine

KW - Febrile episode

KW - Myelodysplastic syndrome

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Decreased incidence of febrile episodes with antibiotic prophylaxis in the treatment of decitabine for myelodysplastic syndrome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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