TY - JOUR
T1 - Decreased NURR1 gene expression in patients with Parkinson's disease
AU - Le, Weidong
AU - Pan, Tianhong
AU - Huang, Maosheng
AU - Xu, Pingyi
AU - Xie, Wenjie
AU - Zhu, Wen
AU - Zhang, Xiong
AU - Deng, Hao
AU - Jankovic, Joseph
N1 - Funding Information:
This study was supported by a grant from the American Parkinson Disease Association of Post-doc fellow (2003), grants from NINSD-40370, NINSD-043567, and a research grant from M J Fox Foundation for Parkinson's Research and Diana Helis Henry Medical Research Foundation (2007). We thank patients and Christine Hunter, Kevin Nguyen-Vuong, Karen Flores and other staff members of the Parkinson's Disease Center and Movement Disorder Clinic of Baylor College of Medicine for their assistance with this project. We also thank Drs David Chiu, Rachell Doody, Dennis Mosier, William Ondo, Larry Schneider, and Jinwu Zhang (Department of Neurology, Baylor College of Medicine) for some of the blood samples and information on patients as disease controls.
PY - 2008/10/15
Y1 - 2008/10/15
N2 - NURR1 is a transcription factor essential for the development, survival, and functional maintenance of midbrain dopaminergic (DAergic) neurons and NURR1 is a potential susceptibility gene for Parkinson's disease (PD). To determine whether NURR1 gene expression is altered in patients with PD, we measured its expression in human peripheral blood lymphocytes (PBL) in 278 patients with PD, 166 healthy controls (HC), and 256 neurological disease controls (NDC) by quantitative real-time PCR. NURR1 gene expression was significantly decreased in patients with PD (particularly those with family history of PD) as compared with HC (p < 0.01) and also as compared with NDC (p < 0.05). There was no significant difference in NURR1 gene expression among PD patients with or without anti-PD medications. When adjusted for gender, age, and ethnicity, lower levels of NURR1 gene expression were associated with significantly increased risk for PD in women, in patients 60 years old or older, and in patients of Caucasian origin. The observed reduction in PBL NURR1 gene expression indicates possible systemic involvement in PD, and the finding may help identify individuals with PD and other disorders associated with impaired central DAergic system.
AB - NURR1 is a transcription factor essential for the development, survival, and functional maintenance of midbrain dopaminergic (DAergic) neurons and NURR1 is a potential susceptibility gene for Parkinson's disease (PD). To determine whether NURR1 gene expression is altered in patients with PD, we measured its expression in human peripheral blood lymphocytes (PBL) in 278 patients with PD, 166 healthy controls (HC), and 256 neurological disease controls (NDC) by quantitative real-time PCR. NURR1 gene expression was significantly decreased in patients with PD (particularly those with family history of PD) as compared with HC (p < 0.01) and also as compared with NDC (p < 0.05). There was no significant difference in NURR1 gene expression among PD patients with or without anti-PD medications. When adjusted for gender, age, and ethnicity, lower levels of NURR1 gene expression were associated with significantly increased risk for PD in women, in patients 60 years old or older, and in patients of Caucasian origin. The observed reduction in PBL NURR1 gene expression indicates possible systemic involvement in PD, and the finding may help identify individuals with PD and other disorders associated with impaired central DAergic system.
KW - Biomarkers
KW - Dopaminergic neurons
KW - Parkinson's disease
KW - Peripheral blood lymphocytes
KW - Transcription factor
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U2 - 10.1016/j.jns.2008.06.007
DO - 10.1016/j.jns.2008.06.007
M3 - Article
C2 - 18684475
AN - SCOPUS:50149097574
SN - 0022-510X
VL - 273
SP - 29
EP - 33
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -