TY - JOUR
T1 - Defective T suppressor-inducer cell function in human immune deficiency virus-seropositive hemophilia patients
AU - Sjamsoedin-Visser, L. J.M.
AU - Heijnen, C. J.
AU - Zegers, B. J.M.
AU - Stoop, J. W.
PY - 1988
Y1 - 1988
N2 - In human immune deficiency virus (HIV)-seropositive hemophilia patients, a low number of CD4+ lymphocytes is found, as well as a low CD4+/CD8+ ratio. In previous studies, it has been shown that antigen-specific T-helper cell (CD4+) function was present and no excessive antigen-specific T-suppressor cell (CD8+) function could be demonstrated. In this report, we studied another activity of CD4+ cells, namely the capacity to induce T-suppressor cell activity. The results clearly show a selective dysfunction of CD4+ suppressor-inducer (Tsi) cell function. Since these HIV-seropositive hemophilia patients showed the presence of activated B cells in the peripheral circulation refractory to antigen-specific T-helper cell signals and secreting specific antibodies spontaneously, we raised the hypothesis that the activated B cells in the patients activate the Tsi cells in vivo. This constant activation leads to a functional exhaustion of the Tsi cell pool.
AB - In human immune deficiency virus (HIV)-seropositive hemophilia patients, a low number of CD4+ lymphocytes is found, as well as a low CD4+/CD8+ ratio. In previous studies, it has been shown that antigen-specific T-helper cell (CD4+) function was present and no excessive antigen-specific T-suppressor cell (CD8+) function could be demonstrated. In this report, we studied another activity of CD4+ cells, namely the capacity to induce T-suppressor cell activity. The results clearly show a selective dysfunction of CD4+ suppressor-inducer (Tsi) cell function. Since these HIV-seropositive hemophilia patients showed the presence of activated B cells in the peripheral circulation refractory to antigen-specific T-helper cell signals and secreting specific antibodies spontaneously, we raised the hypothesis that the activated B cells in the patients activate the Tsi cells in vivo. This constant activation leads to a functional exhaustion of the Tsi cell pool.
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U2 - 10.1182/blood.v72.5.1474.1474
DO - 10.1182/blood.v72.5.1474.1474
M3 - Article
C2 - 2902886
AN - SCOPUS:0023698747
SN - 0006-4971
VL - 72
SP - 1474
EP - 1477
JO - Blood
JF - Blood
IS - 5
ER -