TY - JOUR
T1 - Delayed bolus-tracking trigger at CT correlates with cardiac dysfunction and suboptimal portovenous contrast phase
AU - Jensen, Corey T.
AU - Khetan, Rahul
AU - Adkins, Jake
AU - Javadi, Sanaz
AU - Liu, Xinming
AU - Sun, Jia
AU - Hassan, Saamir A.
AU - Morani, Ajaykumar C.
N1 - Funding Information:
Supported by institutional CCSG (cancer center support grant) from the NIH/National Cancer Institute under award number P30CA016672. Acknowledgements
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/2
Y1 - 2021/2
N2 - Objective: To assess whether delayed trigger during bolus-tracking for CT correlates with reduced heart function and suboptimal portovenous contrast phase. Methods and Materials: Patients who underwent portovenous abdominal CT using bolus-tracking and echocardiography within 2 weeks were included and excluded if there was a non-standard contrast injection. The bolus trigger time (BTT) at 100 Hounsfield units in the abdominal aorta, patient age, congestive heart failure (CHF) history, and ejection fraction were recorded. Two radiologists scored the liver contrast phase (1–5, 5 being an optimal portovenous phase). When applicable, the BTT and contrast score of the most recent comparison examination with equivalent technical parameters were also recorded. Simple linear regression (univariate) was used to test for associations with trigger time. Results: 114 patients with a mean age of 61 ± 15 years fulfilled criteria. The mean trigger time was 18 ± 6 s (range: 6–38 s) and the mean ejection fraction was 52 ± 12% (range: 19–69%). A longer bolus trigger had a significant correlation with reduced ejection fraction (P = 0.0018), lower hepatic contrast score (P < 0.0001), history of CHF (P = 0.0212), and older age (P = 0.0223). Contrast score differences between the study exam and available prior exams revealed score differences of 0 (n = 73), 1 (n = 15) and 2 (n = 5); these were associated, respectively, with a mean bolus trigger time difference between exams of 2 s (range, 0–6 s), 6 s (range, 1–15 s), and 11 s (range, 5–13). The P-value comparing bolus trigger time and contrast score differences was less than 0.0001. A lower ejection fraction also significantly correlated with suboptimal PV contrast phase (P < 0.0001). Conclusion: Delayed time to trigger during bolus-tracking for CT can indicate cardiac dysfunction and may not adequately adjust to provide an optimal portovenous contrast phase.
AB - Objective: To assess whether delayed trigger during bolus-tracking for CT correlates with reduced heart function and suboptimal portovenous contrast phase. Methods and Materials: Patients who underwent portovenous abdominal CT using bolus-tracking and echocardiography within 2 weeks were included and excluded if there was a non-standard contrast injection. The bolus trigger time (BTT) at 100 Hounsfield units in the abdominal aorta, patient age, congestive heart failure (CHF) history, and ejection fraction were recorded. Two radiologists scored the liver contrast phase (1–5, 5 being an optimal portovenous phase). When applicable, the BTT and contrast score of the most recent comparison examination with equivalent technical parameters were also recorded. Simple linear regression (univariate) was used to test for associations with trigger time. Results: 114 patients with a mean age of 61 ± 15 years fulfilled criteria. The mean trigger time was 18 ± 6 s (range: 6–38 s) and the mean ejection fraction was 52 ± 12% (range: 19–69%). A longer bolus trigger had a significant correlation with reduced ejection fraction (P = 0.0018), lower hepatic contrast score (P < 0.0001), history of CHF (P = 0.0212), and older age (P = 0.0223). Contrast score differences between the study exam and available prior exams revealed score differences of 0 (n = 73), 1 (n = 15) and 2 (n = 5); these were associated, respectively, with a mean bolus trigger time difference between exams of 2 s (range, 0–6 s), 6 s (range, 1–15 s), and 11 s (range, 5–13). The P-value comparing bolus trigger time and contrast score differences was less than 0.0001. A lower ejection fraction also significantly correlated with suboptimal PV contrast phase (P < 0.0001). Conclusion: Delayed time to trigger during bolus-tracking for CT can indicate cardiac dysfunction and may not adequately adjust to provide an optimal portovenous contrast phase.
KW - Abdomen
KW - Bolus-tracking
KW - CT
KW - Congestive heart failure
KW - Contrast
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U2 - 10.1007/s00261-020-02655-8
DO - 10.1007/s00261-020-02655-8
M3 - Article
C2 - 32700213
AN - SCOPUS:85088392927
SN - 2366-004X
VL - 46
SP - 826
EP - 835
JO - Abdominal Radiology
JF - Abdominal Radiology
IS - 2
ER -