Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis

Medicine & Life Sciences

• Gluconeogenesis 100%
• Glycolysis 86%
• Up-Regulation 59%
• Down-Regulation 57%
• Glucose 52%
• Liver 42%
• Transcription Factor 3 34%
• Genes 33%
• Glucokinase 32%
• Sirtuins 31%
• Transcription Factor 4 17%
• Homeostasis 17%
• Forkhead Transcription Factors 15%
• Ectopic Gene Expression 13%
• Pyruvic Acid 12%
• Glucose Intolerance 12%
• High Fat Diet 11%
• Knockout Mice 10%
• Blood Glucose 9%
• Fasting 9%
• Type 2 Diabetes Mellitus 8%
• Oxidative Stress 8%
• Diet 8%
• Insulin 8%
• Phenotype 7%

Agriculture & Biology

• gluconeogenesis 97%
• glycolysis 83%
• glucose 49%
• liver 48%
• metabolism 48%
• mice 47%
• glucokinase 28%
• genes 28%
• homeostasis 17%
• transcription factors 16%
• glucose tolerance 14%
• noninsulin-dependent diabetes mellitus 13%
• liver function 12%
• aerobiosis 11%
• high fat diet 11%
• blood glucose 10%
• pyruvates 10%
• fasting 10%
• insulin 9%
• oxidative stress 8%
• phenotype 6%
• diet 5%

Chemistry

• Pharmacological Metabolism 63%
• Glucose 60%
• Pyruvate 10%
• Antioxidant Agent 7%