TY - JOUR
T1 - Deletion of TAK1 in the Myeloid Lineage Results in the Spontaneous Development of Myelomonocytic Leukemia in Mice
AU - Lamothe, Betty
AU - Lai, Yun Ju
AU - Hur, Lana
AU - Orozco, Natalia Martin
AU - Wang, Jing
AU - Campos, Alejandro D.
AU - Xie, Min
AU - Schneider, Michael D.
AU - Lockworth, Cynthia R.
AU - Jakacky, Jared
AU - Tran, Diep
AU - Ho, Michael
AU - Dawud, Sity
AU - Dong, Chen
AU - Lin, Hui Kuan
AU - Hu, Peter
AU - Estrov, Zeev
AU - Bueso-Ramos, Carlos E.
AU - Darnay, Bryant G.
PY - 2012/12/10
Y1 - 2012/12/10
N2 - Previous studies of the conditional ablation of TGF-β activated kinase 1 (TAK1) in mice indicate that TAK1 has an obligatory role in the survival and/or development of hematopoietic stem cells, B cells, T cells, hepatocytes, intestinal epithelial cells, keratinocytes, and various tissues, primarily because of these cells' increased apoptotic sensitivity, and have implicated TAK1 as a critical regulator of the NF-κB and stress kinase pathways and thus a key intermediary in cellular survival. Contrary to this understanding of TAK1's role, we report a mouse model in which TAK1 deletion in the myeloid compartment that evoked a clonal myelomonocytic cell expansion, splenomegaly, multi-organ infiltration, genomic instability, and aggressive, fatal myelomonocytic leukemia. Unlike in previous reports, simultaneous deletion of TNF receptor 1 (TNFR1) failed to rescue this severe phenotype. We found that the features of the disease in our mouse model resemble those of human chronic myelomonocytic leukemia (CMML) in its transformation to acute myeloid leukemia (AML). Consequently, we found TAK1 deletion in 13 of 30 AML patients (43%), thus providing direct genetic evidence of TAK1's role in leukemogenesis.
AB - Previous studies of the conditional ablation of TGF-β activated kinase 1 (TAK1) in mice indicate that TAK1 has an obligatory role in the survival and/or development of hematopoietic stem cells, B cells, T cells, hepatocytes, intestinal epithelial cells, keratinocytes, and various tissues, primarily because of these cells' increased apoptotic sensitivity, and have implicated TAK1 as a critical regulator of the NF-κB and stress kinase pathways and thus a key intermediary in cellular survival. Contrary to this understanding of TAK1's role, we report a mouse model in which TAK1 deletion in the myeloid compartment that evoked a clonal myelomonocytic cell expansion, splenomegaly, multi-organ infiltration, genomic instability, and aggressive, fatal myelomonocytic leukemia. Unlike in previous reports, simultaneous deletion of TNF receptor 1 (TNFR1) failed to rescue this severe phenotype. We found that the features of the disease in our mouse model resemble those of human chronic myelomonocytic leukemia (CMML) in its transformation to acute myeloid leukemia (AML). Consequently, we found TAK1 deletion in 13 of 30 AML patients (43%), thus providing direct genetic evidence of TAK1's role in leukemogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84870922929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870922929&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0051228
DO - 10.1371/journal.pone.0051228
M3 - Article
C2 - 23251462
AN - SCOPUS:84870922929
SN - 1932-6203
VL - 7
JO - PloS one
JF - PloS one
IS - 12
M1 - e51228
ER -