TY - JOUR
T1 - Demographics and clinical characteristics of acute traumatic brain injury patients in the different Neuroimaging Radiological Interpretation System (NIRIS) categories
AU - Chen, Hui
AU - Li, Ying
AU - Jiang, Bin
AU - Zhu, Guangming
AU - Rezaii, Paymon Garakani
AU - Lu, Gang
AU - Wintermark, Max
N1 - Funding Information:
Dr. Hui Chen is supported by a grant from the National Natural Science Foundations of China (Grant No. 81771273 ).
Publisher Copyright:
© 2019 Elsevier Masson SAS
PY - 2021/3
Y1 - 2021/3
N2 - Purpose: To characterize the demographics, clinical and imaging findings, and outcomes of traumatic brain injury (TBI) patients in each of NeuroImaging Radiological Interpretation System (NIRIS) categories. Material and methods: We considered all consecutive patients transported to Stanford Hospital's emergency department by ambulance or helicopter between November 2015 and April 2017. We retained adult patients (> 18 years old) for whom a trauma alert was triggered and who underwent a non-contrast head computer tomography (CT) because of suspected TBI. We reviewed the non-contrast CT scans in these patients for the NIH TBI common data elements (CDEs). We recorded, then assessed differences in terms of demographics, clinical characteristics, imaging CDEs, and outcomes in patients from the different NIRIS categories. Results: In all, 1152 patients were included in this study. Patients with NIRIS 0 imaging findings were significantly younger than patients in other NIRIS categories (P < 0.001). Motor vehicle accidents and falls from height were the most common mechanisms of injury across NIRIS categories. GCS scores decreased with increasing NIRIS category imaging findings and were significantly lower in patients with NIRIS 4 imaging findings (P < 0.001). Significant differences in NIRIS categories were observed for all imaging CDEs (P < 0.001), in agreement with the definition of the different NIRIS categories. Mortality increased progressively with increasing NIRIS severity. Conclusions: TBI patients in different NIRIS categories have different clinical characteristics, hospital courses and outcomes. This natural history assessment of patients from different NIRIS categories could thus serve as a reference standard for future TBI clinical trials.
AB - Purpose: To characterize the demographics, clinical and imaging findings, and outcomes of traumatic brain injury (TBI) patients in each of NeuroImaging Radiological Interpretation System (NIRIS) categories. Material and methods: We considered all consecutive patients transported to Stanford Hospital's emergency department by ambulance or helicopter between November 2015 and April 2017. We retained adult patients (> 18 years old) for whom a trauma alert was triggered and who underwent a non-contrast head computer tomography (CT) because of suspected TBI. We reviewed the non-contrast CT scans in these patients for the NIH TBI common data elements (CDEs). We recorded, then assessed differences in terms of demographics, clinical characteristics, imaging CDEs, and outcomes in patients from the different NIRIS categories. Results: In all, 1152 patients were included in this study. Patients with NIRIS 0 imaging findings were significantly younger than patients in other NIRIS categories (P < 0.001). Motor vehicle accidents and falls from height were the most common mechanisms of injury across NIRIS categories. GCS scores decreased with increasing NIRIS category imaging findings and were significantly lower in patients with NIRIS 4 imaging findings (P < 0.001). Significant differences in NIRIS categories were observed for all imaging CDEs (P < 0.001), in agreement with the definition of the different NIRIS categories. Mortality increased progressively with increasing NIRIS severity. Conclusions: TBI patients in different NIRIS categories have different clinical characteristics, hospital courses and outcomes. This natural history assessment of patients from different NIRIS categories could thus serve as a reference standard for future TBI clinical trials.
KW - Clinical characteristics
KW - Computed tomography
KW - CT
KW - Demographics
KW - TBI
KW - Traumatic brain injury
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U2 - 10.1016/j.neurad.2019.07.002
DO - 10.1016/j.neurad.2019.07.002
M3 - Article
C2 - 31323305
AN - SCOPUS:85069668180
SN - 0150-9861
VL - 48
SP - 104
EP - 111
JO - Journal of Neuroradiology
JF - Journal of Neuroradiology
IS - 2
ER -