TY - JOUR
T1 - Depressive symptoms enhance stress-induced inflammatory responses
AU - Fagundes, Christopher P.
AU - Glaser, Ronald
AU - Hwang, Beom Seuk
AU - Malarkey, William B.
AU - Kiecolt-Glaser, Janice K.
N1 - Funding Information:
Work on this project was supported in part by NIH grants R01AG029562, CA131029, CA126857, DE014320, UL1RR025755, CA016058, the S. Robert Davis endowment, the Kathryn & Gilbert Mitchell endowment, and American Cancer Society Postdoctoral Fellowship Grant PF-11-007-01-CPPB.
PY - 2013/7
Y1 - 2013/7
N2 - Depression is a risk factor for morbidity and mortality, and immune dysregulation may be partially responsible for this link. Proinflammatory cytokines such as interleukin 6 (IL-6) are reliable predictors of quality of life, morbidity, and many causes of mortality. The current study evaluated relationships between depressive symptoms, as assessed by the CES-D, and stress-induced inflammation. The participants, 138 healthy adults, were evaluated at rest, and after a standardized laboratory speech and mental arithmetic stressor. Compared with individuals with fewer depressive symptoms, those with more depressive symptoms produced more IL-6 in response to the stressor, as well as significantly higher levels of IL-6 both 45. min and 2. h after the stressor. These findings add to our emerging understanding of the complex interactions among stress, depression, and immune dysregulation, and provide one potential pathway to explain relationships between depressive symptoms and disease.
AB - Depression is a risk factor for morbidity and mortality, and immune dysregulation may be partially responsible for this link. Proinflammatory cytokines such as interleukin 6 (IL-6) are reliable predictors of quality of life, morbidity, and many causes of mortality. The current study evaluated relationships between depressive symptoms, as assessed by the CES-D, and stress-induced inflammation. The participants, 138 healthy adults, were evaluated at rest, and after a standardized laboratory speech and mental arithmetic stressor. Compared with individuals with fewer depressive symptoms, those with more depressive symptoms produced more IL-6 in response to the stressor, as well as significantly higher levels of IL-6 both 45. min and 2. h after the stressor. These findings add to our emerging understanding of the complex interactions among stress, depression, and immune dysregulation, and provide one potential pathway to explain relationships between depressive symptoms and disease.
KW - Depression
KW - Proinflammatory cytokines
KW - Psychoneuroimmunology
KW - Stress
KW - Trier social stress test
UR - http://www.scopus.com/inward/record.url?scp=84878127837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878127837&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2012.05.006
DO - 10.1016/j.bbi.2012.05.006
M3 - Article
C2 - 22634107
AN - SCOPUS:84878127837
SN - 0889-1591
VL - 31
SP - 172
EP - 176
JO - Brain, behavior, and immunity
JF - Brain, behavior, and immunity
ER -