Dermatopathologic features of cutaneous squamous cell carcinoma and actinic keratosis: Consensus criteria and proposed reporting guidelines

Rachel E. Christensen; Dirk M. Elston; Brandon Worley; McKenzie A. Dirr; Noor Anvery; Bianca Y. Kang; Soon Bahrami; Robert T. Brodell; Lorenzo Cerroni; Carly Elston; Tammie Ferringer; M. Yadira Hurley; Kyle Garton; Joyce Siong See Lee; Yeqiang Liu; John C. Maize; Jennifer M. McNiff; Ronald P. Rapini; Omar P. Sangueza; Christopher R. Shea; Cheng Zhou; Murad Alam

doi:10.1016/j.jaad.2022.12.057

Dermatopathologic features of cutaneous squamous cell carcinoma and actinic keratosis: Consensus criteria and proposed reporting guidelines

Rachel E. Christensen, Dirk M. Elston, Brandon Worley, McKenzie A. Dirr, Noor Anvery, Bianca Y. Kang, Soon Bahrami, Robert T. Brodell, Lorenzo Cerroni, Carly Elston, Tammie Ferringer, M. Yadira Hurley, Kyle Garton, Joyce Siong See Lee, Yeqiang Liu, John C. Maize, Jennifer M. McNiff, Ronald P. Rapini, Omar P. Sangueza, Christopher R. SheaCheng Zhou, Murad Alam

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: There is considerable variation in the literature regarding the dermatopathologic diagnostic features of and reporting guidelines for actinic keratosis (AK) and cutaneous squamous cell carcinoma (cSCC). Objective: To develop consensus recommendations regarding diagnostic criteria, nomenclature, and reporting of AK and cSCC. Methods: Literature review and cross-sectional multiround Delphi process including an international group of expert dermatopathologists followed by a consensus meeting. Results: Consensus was achieved regarding the key dermatopathologic features necessary for diagnosing cSCC, AK, and associated variants; grading of degree of cellular differentiation in cSCC; utility of immunohistochemistry for diagnosis of cSCC; and pathologic features that should be reported for cSCC and AK. Limitations: Consensus was not achieved on all questions considered. Conclusion: Despite the lack of clarity in the literature, there is consensus among expert dermatopathologists regarding diagnostic criteria and appropriate reporting of AK and cSCC. Widespread implementation of these consensus recommendations may improve communication between dermatopathologists and clinicians, facilitating appropriate treatment of AK and cSCC.

Original language	English (US)
Pages (from-to)	1317-1325
Number of pages	9
Journal	Journal of the American Academy of Dermatology
Volume	88
Issue number	6
DOIs	https://doi.org/10.1016/j.jaad.2022.12.057
State	Published - Jun 2023
Externally published	Yes

Keywords

actinic keratosis
consensus
diagnosis
immunohistochemistry
international
pathology
squamous cell carcinoma

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2022.12.057

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Christensen, R. E., Elston, D. M., Worley, B., Dirr, M. A., Anvery, N., Kang, B. Y., Bahrami, S., Brodell, R. T., Cerroni, L., Elston, C., Ferringer, T., Hurley, M. Y., Garton, K., Lee, J. S. S., Liu, Y., Maize, J. C., McNiff, J. M., Rapini, R. P., Sangueza, O. P., ... Alam, M. (2023). Dermatopathologic features of cutaneous squamous cell carcinoma and actinic keratosis: Consensus criteria and proposed reporting guidelines. Journal of the American Academy of Dermatology, 88(6), 1317-1325. https://doi.org/10.1016/j.jaad.2022.12.057

Christensen, RE, Elston, DM, Worley, B, Dirr, MA, Anvery, N, Kang, BY, Bahrami, S, Brodell, RT, Cerroni, L, Elston, C, Ferringer, T, Hurley, MY, Garton, K, Lee, JSS, Liu, Y, Maize, JC, McNiff, JM, Rapini, RP, Sangueza, OP, Shea, CR, Zhou, C & Alam, M 2023, 'Dermatopathologic features of cutaneous squamous cell carcinoma and actinic keratosis: Consensus criteria and proposed reporting guidelines', Journal of the American Academy of Dermatology, vol. 88, no. 6, pp. 1317-1325. https://doi.org/10.1016/j.jaad.2022.12.057

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title = "Dermatopathologic features of cutaneous squamous cell carcinoma and actinic keratosis: Consensus criteria and proposed reporting guidelines",

abstract = "Background: There is considerable variation in the literature regarding the dermatopathologic diagnostic features of and reporting guidelines for actinic keratosis (AK) and cutaneous squamous cell carcinoma (cSCC). Objective: To develop consensus recommendations regarding diagnostic criteria, nomenclature, and reporting of AK and cSCC. Methods: Literature review and cross-sectional multiround Delphi process including an international group of expert dermatopathologists followed by a consensus meeting. Results: Consensus was achieved regarding the key dermatopathologic features necessary for diagnosing cSCC, AK, and associated variants; grading of degree of cellular differentiation in cSCC; utility of immunohistochemistry for diagnosis of cSCC; and pathologic features that should be reported for cSCC and AK. Limitations: Consensus was not achieved on all questions considered. Conclusion: Despite the lack of clarity in the literature, there is consensus among expert dermatopathologists regarding diagnostic criteria and appropriate reporting of AK and cSCC. Widespread implementation of these consensus recommendations may improve communication between dermatopathologists and clinicians, facilitating appropriate treatment of AK and cSCC.",

keywords = "actinic keratosis, consensus, diagnosis, immunohistochemistry, international, pathology, squamous cell carcinoma",

author = "Christensen, {Rachel E.} and Elston, {Dirk M.} and Brandon Worley and Dirr, {McKenzie A.} and Noor Anvery and Kang, {Bianca Y.} and Soon Bahrami and Brodell, {Robert T.} and Lorenzo Cerroni and Carly Elston and Tammie Ferringer and Hurley, {M. Yadira} and Kyle Garton and Lee, {Joyce Siong See} and Yeqiang Liu and Maize, {John C.} and McNiff, {Jennifer M.} and Rapini, {Ronald P.} and Sangueza, {Omar P.} and Shea, {Christopher R.} and Cheng Zhou and Murad Alam",

note = "Publisher Copyright: {\textcopyright} 2023 American Academy of Dermatology, Inc.",

year = "2023",

month = jun,

doi = "10.1016/j.jaad.2022.12.057",

language = "English (US)",

volume = "88",

pages = "1317--1325",

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T1 - Dermatopathologic features of cutaneous squamous cell carcinoma and actinic keratosis

T2 - Consensus criteria and proposed reporting guidelines

AU - Christensen, Rachel E.

AU - Elston, Dirk M.

AU - Worley, Brandon

AU - Dirr, McKenzie A.

AU - Anvery, Noor

AU - Kang, Bianca Y.

AU - Bahrami, Soon

AU - Brodell, Robert T.

AU - Cerroni, Lorenzo

AU - Elston, Carly

AU - Ferringer, Tammie

AU - Hurley, M. Yadira

AU - Garton, Kyle

AU - Lee, Joyce Siong See

AU - Liu, Yeqiang

AU - Maize, John C.

AU - McNiff, Jennifer M.

AU - Rapini, Ronald P.

AU - Sangueza, Omar P.

AU - Shea, Christopher R.

AU - Zhou, Cheng

AU - Alam, Murad

PY - 2023/6

Y1 - 2023/6

N2 - Background: There is considerable variation in the literature regarding the dermatopathologic diagnostic features of and reporting guidelines for actinic keratosis (AK) and cutaneous squamous cell carcinoma (cSCC). Objective: To develop consensus recommendations regarding diagnostic criteria, nomenclature, and reporting of AK and cSCC. Methods: Literature review and cross-sectional multiround Delphi process including an international group of expert dermatopathologists followed by a consensus meeting. Results: Consensus was achieved regarding the key dermatopathologic features necessary for diagnosing cSCC, AK, and associated variants; grading of degree of cellular differentiation in cSCC; utility of immunohistochemistry for diagnosis of cSCC; and pathologic features that should be reported for cSCC and AK. Limitations: Consensus was not achieved on all questions considered. Conclusion: Despite the lack of clarity in the literature, there is consensus among expert dermatopathologists regarding diagnostic criteria and appropriate reporting of AK and cSCC. Widespread implementation of these consensus recommendations may improve communication between dermatopathologists and clinicians, facilitating appropriate treatment of AK and cSCC.

AB - Background: There is considerable variation in the literature regarding the dermatopathologic diagnostic features of and reporting guidelines for actinic keratosis (AK) and cutaneous squamous cell carcinoma (cSCC). Objective: To develop consensus recommendations regarding diagnostic criteria, nomenclature, and reporting of AK and cSCC. Methods: Literature review and cross-sectional multiround Delphi process including an international group of expert dermatopathologists followed by a consensus meeting. Results: Consensus was achieved regarding the key dermatopathologic features necessary for diagnosing cSCC, AK, and associated variants; grading of degree of cellular differentiation in cSCC; utility of immunohistochemistry for diagnosis of cSCC; and pathologic features that should be reported for cSCC and AK. Limitations: Consensus was not achieved on all questions considered. Conclusion: Despite the lack of clarity in the literature, there is consensus among expert dermatopathologists regarding diagnostic criteria and appropriate reporting of AK and cSCC. Widespread implementation of these consensus recommendations may improve communication between dermatopathologists and clinicians, facilitating appropriate treatment of AK and cSCC.

KW - actinic keratosis

KW - consensus

KW - diagnosis

KW - immunohistochemistry

KW - international

KW - pathology

KW - squamous cell carcinoma

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JF - Journal of the American Academy of Dermatology

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ER -

Dermatopathologic features of cutaneous squamous cell carcinoma and actinic keratosis: Consensus criteria and proposed reporting guidelines

Abstract

Keywords

ASJC Scopus subject areas

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