Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase

Medicine & Life Sciences

• 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide 100%
• p31 integrase protein, Human immunodeficiency virus 1 60%
• Integrase Inhibitors 58%
• HIV Integrase Inhibitors 16%
• Raltegravir Potassium 14%
• Catalysis 11%
• Drug Resistance 8%
• Metals 8%
• Antiviral Agents 8%
• Viruses 6%
• Clinical Trials 6%
• Safety 5%
• Mutation 5%
• Pharmaceutical Preparations 4%

Chemistry

• Integrase Inhibitor 61%
• Transfer Reaction 14%
• Raltegravir 13%
• Mutation 6%
• Strain 5%
• Catalysis 4%
• Metal 3%