@article{5ca1134d5cab401fa3a3d5fc3ef50826,
title = "Design and interpretation of linkage and association studies on osteoporosis",
abstract = "Osteoporosis is a common disease with strong genetic control. Genetic linkage and association studies are the two most popular methods used to investigate the genetic basis of osteoporosis. Linkage studies have been successfully used to identify quantitative trait loci (QTLs), and association studies have been widely performed to test candidate genes for osteoporosis. In this article, we review the design and interpretation of linkage and association studies on osteoporosis.",
keywords = "Association, Interpretation, Linkage, Osteoporosis, Study design",
author = "Ting Xu and Yu Cheng and Yan Guo and Lei Zhang and Pei, {Yu Fang} and Kirk Redger and Liu, {Yong Jun} and Deng, {Hong Wen}",
note = "Funding Information: Acknowledgments Investigators of this work were partially supported by grants from NIH (R01AR050496, R21AG027110, R01AG026564, R21AA015973, R01AR057049, RC2DE020756 and R03TW008221) and a SCOR (Specialized Center of Research) grant (P50 AR055081) supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the Office of Research on Women{\textquoteright}s Health (ORWH). The study also benefited from grants from National Science Foundation of China, Huo Ying Dong Education Foundation, HuNan Province, Xi{\textquoteright}an Jiaotong University, the Ministry of Education of China, Shanghai Leading Academic Discipline Project (S30501) and start-up fund from Shanghai University of Science and Technology.",
year = "2010",
month = jun,
doi = "10.1007/s12018-010-9070-6",
language = "English (US)",
volume = "8",
pages = "60--67",
journal = "Clinical Reviews in Bone and Mineral Metabolism",
issn = "1534-8644",
publisher = "Humana Press",
number = "2",
}