Abstract
Mimetics of phosphotyrosine (pTyr) such as phosphonomethylphenylalanine (Pmp) have traditionally retained α-amino functionality. However, β-amino acids represent isomeric variants, which may exhibit properties that are distinct from the parent. Reported herein is the first β-amino pTyr mimetic (Pmpβ) bearing protection suitable for peptide synthesis. Preparation of Pmpβ was accomplished enantioselectively in 43% overall yield from commercially available 4-vinylbenzyl chloride.
Original language | English (US) |
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Pages (from-to) | 3399-3401 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 12 |
Issue number | 23 |
DOIs | |
State | Published - Dec 2002 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry