TY - JOUR
T1 - Design, synthesis and biological evaluation of novel 2,3-indolinedione derivatives against mantle cell lymphoma
AU - Yu, Shengping
AU - Liu, Yang
AU - Zhang, Zhen
AU - Zhang, Jingya
AU - Zhao, Guisen
N1 - Funding Information:
This work was supported by the key research and development project of Shandong Province (No. 2017CXGC1401 ).
Funding Information:
This work was supported by the key research and development project of Shandong Province (No. 2017CXGC1401).
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/8/1
Y1 - 2019/8/1
N2 - 2,3-Indolinedione derivatives have been identified as a novel class of promising agents for cancer treatment. In this study, eighteen 2,3-indolinedione derivatives were designed and synthesized, and their anticancer activities against mantle cell lymphoma (MCL) cells were evaluated. Most of them exhibited significant antiproliferative activity against the tested cell lines, and compound K5 was the most potent (MCL cellular IC50 = 0.4–0.7 μM). Further, compound K5 could induce cell apoptosis and cell cycle arrest in G2/M phase. Additionally, the results of drug-likeness analysis demonstrated that these novel 2,3-indolinedione derivatives could have potential as novel treatment strategies for MCL.
AB - 2,3-Indolinedione derivatives have been identified as a novel class of promising agents for cancer treatment. In this study, eighteen 2,3-indolinedione derivatives were designed and synthesized, and their anticancer activities against mantle cell lymphoma (MCL) cells were evaluated. Most of them exhibited significant antiproliferative activity against the tested cell lines, and compound K5 was the most potent (MCL cellular IC50 = 0.4–0.7 μM). Further, compound K5 could induce cell apoptosis and cell cycle arrest in G2/M phase. Additionally, the results of drug-likeness analysis demonstrated that these novel 2,3-indolinedione derivatives could have potential as novel treatment strategies for MCL.
KW - 2,3-Indolinedione
KW - Biological activities
KW - Derivatives
KW - Mantle cell lymphoma
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U2 - 10.1016/j.bmc.2019.06.009
DO - 10.1016/j.bmc.2019.06.009
M3 - Article
C2 - 31229421
AN - SCOPUS:85067369212
SN - 0968-0896
VL - 27
SP - 3319
EP - 3327
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 15
ER -