TY - JOUR
T1 - Design, synthesis, and diversification of 3,5-substituted enone library
AU - Khalaf, Juhienah
AU - Estrella-Jimenez, Maria E.
AU - Shashack, Matthew J.
AU - Phatak, Sharangdhar S.
AU - Zhang, Shuxing
AU - Gilbertson, Scott R.
PY - 2011/7/11
Y1 - 2011/7/11
N2 - This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Additionally a small series of triazoles was synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component analysis to examine its diversity.
AB - This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Additionally a small series of triazoles was synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component analysis to examine its diversity.
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U2 - 10.1021/co200070m
DO - 10.1021/co200070m
M3 - Article
C2 - 21648460
AN - SCOPUS:79960251480
SN - 2156-8952
VL - 13
SP - 351
EP - 356
JO - ACS Combinatorial Science
JF - ACS Combinatorial Science
IS - 4
ER -