Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging

Hua Zhu; Jun Zhao; Xinfeng Lin; Ye Hong; Chun Li; Zhi Yang

doi:10.3390/molecules18066425

Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging

Hua Zhu, Jun Zhao, Xinfeng Lin, Ye Hong, Chun Li, Zhi Yang

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

D-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRFCCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.

Original language	English (US)
Pages (from-to)	6425-6438
Number of pages	14
Journal	Molecules
Volume	18
Issue number	6
DOIs	https://doi.org/10.3390/molecules18066425
State	Published - Jun 2013

Keywords

Core-cross-linked polymeric micelles
D-glucosamine
Glyconanoparticles
Indium-111
Tumor imaging agent

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules18066425

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title = "Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging",

abstract = "D-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRFCCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.",

keywords = "Core-cross-linked polymeric micelles, D-glucosamine, Glyconanoparticles, Indium-111, Tumor imaging agent",

author = "Hua Zhu and Jun Zhao and Xinfeng Lin and Ye Hong and Chun Li and Zhi Yang",

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T1 - Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging

AU - Zhu, Hua

AU - Zhao, Jun

AU - Lin, Xinfeng

AU - Hong, Ye

AU - Li, Chun

AU - Yang, Zhi

PY - 2013/6

Y1 - 2013/6

N2 - D-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRFCCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.

AB - D-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRFCCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.

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KW - Glyconanoparticles

KW - Indium-111

KW - Tumor imaging agent

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Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging

Abstract

Keywords

ASJC Scopus subject areas

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