Abstract
We applied a highly sensitive next-generation sequencing method to identify lymphoma-specific immunoglobulin gene segments in classical Hodgkin lymphoma (CHL) at initial diagnosis or recurrence, and assessed the ability of detecting such lymphoma-specific sequences in peripheral blood (PB). Seventeen CHL cases were tested and lymphoma-specific sequences were identified in 12 of the primary tumour biopsies. In 11 of these patients whose paired PB samples were available, tumour-specific clonotypes were detected in PB in eight patients. This data demonstrates the feasibility of detecting circulating tumour-specific sequences, creating an unprecedented opportunity to optimize the future treatment and monitoring strategies for patients with CHL.
Original language | English (US) |
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Pages (from-to) | 689-693 |
Number of pages | 5 |
Journal | British Journal of Haematology |
Volume | 169 |
Issue number | 5 |
DOIs | |
State | Published - Jun 1 2015 |
Keywords
- Hodgkin lymphoma
- Minimal residual disease
- Sequencing
ASJC Scopus subject areas
- Hematology
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