TY - JOUR
T1 - Detection of clonality with κ and λ immunohistochemical analysis in cutaneous plasmacytomas
AU - Bayer-Garner, Ilene B.
AU - Prieto, Victor G.
AU - Smoller, Bruce R.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004
Y1 - 2004
N2 - • Context. - Cutaneous plasmacytomas rarely occur in the setting of multiple myeloma. However, since poorly differentiated lesions may resemble other neoplasms, such as carcinoma, melanoma, and lymphoma, the diagnosis of cutaneous plasmacytoma may be difficult. Objective. - To demonstrate clonality using κ and λ immunohistochemical analysis in cutaneous plasmacytomas and to ascertain whether or not interpretation is hindered by background staining. Design. - Pathology reports of all patients with the diagnosis of multiple myeloma were reviewed. Twelve patients had cutaneous lesions diagnosed as plasmacytoma, and these lesions were analyzed for light chain restriction with κ and λ immunohistochemical analysis. Results. - In most cases (11 of 12), monoclonality was demonstrated. In the remaining case, monoclonality could not be established because most cells did not stain for either κ or λ. Conclusions. - Light chain restriction can be demonstrated in most multiple myeloma-related cutaneous plasma-cytomas, establishing the neoplastic nature of the infiltrate.
AB - • Context. - Cutaneous plasmacytomas rarely occur in the setting of multiple myeloma. However, since poorly differentiated lesions may resemble other neoplasms, such as carcinoma, melanoma, and lymphoma, the diagnosis of cutaneous plasmacytoma may be difficult. Objective. - To demonstrate clonality using κ and λ immunohistochemical analysis in cutaneous plasmacytomas and to ascertain whether or not interpretation is hindered by background staining. Design. - Pathology reports of all patients with the diagnosis of multiple myeloma were reviewed. Twelve patients had cutaneous lesions diagnosed as plasmacytoma, and these lesions were analyzed for light chain restriction with κ and λ immunohistochemical analysis. Results. - In most cases (11 of 12), monoclonality was demonstrated. In the remaining case, monoclonality could not be established because most cells did not stain for either κ or λ. Conclusions. - Light chain restriction can be demonstrated in most multiple myeloma-related cutaneous plasma-cytomas, establishing the neoplastic nature of the infiltrate.
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M3 - Review article
C2 - 15163236
AN - SCOPUS:4844219648
SN - 0003-9985
VL - 128
SP - 645
EP - 648
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 6
ER -