Detection of epstein-barr virus in the L and H cells of nodular lymphocyte predominance Hodgkin's disease: Report of a case documented by immunohistochemical, in situ hybridization, and polymerase chain reaction methods

Hasan S. Khalidi, Mark A. Lones, Yuehua Zhou, Lawrence M. Weiss, L Jeffrey Medeiros

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Although Epstein-Barr virus (EBV) is commonly present in the neoplastic Reed-Sternberg and Hodgkin cells of the mixed cellularity, nodular sclerosis, and lymphocyte depletion types of Hodgkin's disease (HD), EBV is rare in the neoplastic cells of the nodular lymphocyte predominance type of HD, particularly in the United States. We describe a 19-year-old Hispanic man in whom nodular lymphocyte predominance HD involved a cervical lymph node. Epstein-Barr virus was identified in the neoplastic L and H cells by using in situ hybridization for EBV RNA and immunohistochemical staining for EBV latent membrane protein-1. Polymerase chain reaction studies demonstrated the type A strain of EBV. The presence of EBV in this case may be related to drainage of the virus from the oropharynx to the cervical lymph node. The presence of EBV also may be related to this patient's Hispanic ethnic origin.

Original languageEnglish (US)
Pages (from-to)687-692
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume108
Issue number6
DOIs
StatePublished - Jan 1 1997

Keywords

  • Epstein-Barr virus
  • Hodgkin's disease
  • Immunohistochemistry
  • In situ hybridization
  • Nodular lymphocyte predominance
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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