TY - JOUR
T1 - Determination of average LET of therapeutic proton beams using Al 2O3
T2 - C optically stimulated luminescence (OSL) detectors
AU - Sawakuchi, Gabriel O.
AU - Sahoo, Narayan
AU - Gasparian, Patricia B.R.
AU - Rodriguez, Matthew G.
AU - Archambault, Louis
AU - Titt, Uwe
AU - Yukihara, Eduardo G.
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/9/7
Y1 - 2010/9/7
N2 - In this work we present a methodology and proof of concept to experimentally determine average linear energy transfer (LET) of therapeutic proton beams using the optically stimulated luminescence (OSL) of small Al 2O3:C detectors. Our methodology is based on the fact that the shape of the OSL decay curve of Al2O3:C detectors depends on the LET of the radiation field. Thus, one can use the shape of the OSL decay curves to establish an LET calibration curve, which in turn permits measurements of LET. We performed irradiations at the M D Anderson Cancer Center Proton Therapy Center, Houston (PTCH), with passive scattering beams. We determined the average LET of the passive scattering beams using a validated Monte Carlo model of the PTCH passive scattering nozzle and correlated them with the shape of the OSL decay curve to obtain an LET calibration curve. Using this calibration curve and OSL measurements, we determined the averaged LET at various water-equivalent depths for therapeutic spread-out Bragg peaks and compared the results with averaged LETs determined using the Monte Carlo simulations. Agreement between measured and simulated fluence-averaged LET was within 24% for low energy spread-out Bragg peak (SOBP) fields and within 14% for high energy SOBP fields. Agreement between measured and simulated dose-averaged LET was within 12% for low energy SOBP fields and within 47% for high energy SOBP fields. The data presented in this work demonstrated the correlation between the OSL decay curve shapes and the average LET of the radiation fields, providing proof of concept of the feasibility of using OSL from Al 2O3:C detectors to measure average LET of therapeutic proton beams.
AB - In this work we present a methodology and proof of concept to experimentally determine average linear energy transfer (LET) of therapeutic proton beams using the optically stimulated luminescence (OSL) of small Al 2O3:C detectors. Our methodology is based on the fact that the shape of the OSL decay curve of Al2O3:C detectors depends on the LET of the radiation field. Thus, one can use the shape of the OSL decay curves to establish an LET calibration curve, which in turn permits measurements of LET. We performed irradiations at the M D Anderson Cancer Center Proton Therapy Center, Houston (PTCH), with passive scattering beams. We determined the average LET of the passive scattering beams using a validated Monte Carlo model of the PTCH passive scattering nozzle and correlated them with the shape of the OSL decay curve to obtain an LET calibration curve. Using this calibration curve and OSL measurements, we determined the averaged LET at various water-equivalent depths for therapeutic spread-out Bragg peaks and compared the results with averaged LETs determined using the Monte Carlo simulations. Agreement between measured and simulated fluence-averaged LET was within 24% for low energy spread-out Bragg peak (SOBP) fields and within 14% for high energy SOBP fields. Agreement between measured and simulated dose-averaged LET was within 12% for low energy SOBP fields and within 47% for high energy SOBP fields. The data presented in this work demonstrated the correlation between the OSL decay curve shapes and the average LET of the radiation fields, providing proof of concept of the feasibility of using OSL from Al 2O3:C detectors to measure average LET of therapeutic proton beams.
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U2 - 10.1088/0031-9155/55/17/006
DO - 10.1088/0031-9155/55/17/006
M3 - Article
C2 - 20693613
AN - SCOPUS:78149330634
SN - 0031-9155
VL - 55
SP - 4963
EP - 4976
JO - Physics in medicine and biology
JF - Physics in medicine and biology
IS - 17
ER -