Abstract
The measurement of tumor volumes is a practical and objective method of assessing the efficacy of a therapeutic agent. However, the relative accuracy of different methods of assessing tumor volume has been unclear. Using T 1- weighted, gadolinium-enhanced magnetic resonance Imaging (T 1-MRI), Evans Blue infusion and histology we measured intracranial tumor volumes in a rodent brain tumor model (RT2) at days 10, 16 and 18 after implantation of cells in the caudate putamen. There is a good correlation between tumor volumes comparing T 1-MRI and Evans Blue (r 2 = 0.99), T 1-MRI and Histology (r 2 = 0.98) and histology and Evans Blue (r 2 = 0.93). Each of these methods is reliable in estimating tumor volumes in laboratory animals. There was significant uptake of gadolinium and Evans Blue in the tumor suggesting a wide disruption of the blood-brain barrier.
Original language | English (US) |
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Pages (from-to) | 259-265 |
Number of pages | 7 |
Journal | IEEE Transactions on Biomedical Engineering |
Volume | 47 |
Issue number | 2 |
DOIs | |
State | Published - 2000 |
Externally published | Yes |
Keywords
- Blood-brain barrier
- Evans Blue
- Magnetic resonance imaging (MRI)
- Tumor volumes
ASJC Scopus subject areas
- Biomedical Engineering