TY - JOUR
T1 - Development and optimization of near-IR contrast agents for immune cell tracking
AU - Joshi, Pratixa P.
AU - Yoon, Soon Joon
AU - Chen, Yun Sheng
AU - Emelianov, Stanislav
AU - Sokolov, Konstantin V.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Gold nanorods (NRs) are attractive for in vivo imaging due to their high optical cross-sections and tunable absorbance. However, the feasibility of using NRs for cell tracking has not been fully explored. Here, we synthesized dye doped silica-coated NRs as multimodal contrast agents for imaging of macrophages - immune cells which play an important role in cancer and cardiovascular diseases. We showed the importance of silica coating in imaging of NR-labeled cells. Photoacoustic (PA) imaging of NRs labeled macrophages showed high sensitivity. Therefore, these results provide foundation for applications of silica-coated NRs and PA imaging in tracking of immune cells.
AB - Gold nanorods (NRs) are attractive for in vivo imaging due to their high optical cross-sections and tunable absorbance. However, the feasibility of using NRs for cell tracking has not been fully explored. Here, we synthesized dye doped silica-coated NRs as multimodal contrast agents for imaging of macrophages - immune cells which play an important role in cancer and cardiovascular diseases. We showed the importance of silica coating in imaging of NR-labeled cells. Photoacoustic (PA) imaging of NRs labeled macrophages showed high sensitivity. Therefore, these results provide foundation for applications of silica-coated NRs and PA imaging in tracking of immune cells.
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U2 - 10.1364/BOE.4.002609
DO - 10.1364/BOE.4.002609
M3 - Article
C2 - 24298419
AN - SCOPUS:84887208537
SN - 2156-7085
VL - 4
SP - 2609
EP - 2618
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 11
ER -