@inproceedings{a70631f74ea24eb7a905c1ce604aa28f,
title = "Development of a Multi-Modal Electrochemical Sensing (MES) Device for Real-Time Monitoring of Tumor Microenvironment Parameters in Cancer Immunotherapy",
abstract = "This paper introduces a multi-modal electrochemical-based sensing (MES) device for real-time monitoring of the biophysical profile of the tumor microenvironment (TME). The MES device integrates pH, glucose, and impedance sensors onto microneedles. Characterization results show promising sensor performance. MES device performance was illustrated in an in vivo rat subcutaneous tumor model. This device holds the potential for informing pre-clinical studies of cancer immunotherapy by providing real-time TME insights, which may inform the assessment of candidate therapeutic approaches. Future work will explore additional sensors and further validation, paving the way for its use in research and pre-clinical studies.",
keywords = "electrochemical, glucose, impedance sensors, microneedle, Microsensors, pH, real-time monitoring",
author = "Tan, {Jun Ying} and Malea Williams and Mandal, {Santosh Kumar} and Anna Bottiglieri and Aabila Tharzeen and Rahul Sheth and Balasubramaniam Natarajan and Punit Prakash and Kim, {Jungkwun J.K.}",
note = "Publisher Copyright: {\textcopyright} 2024 IEEE.; 37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024 ; Conference date: 21-01-2024 Through 25-01-2024",
year = "2024",
doi = "10.1109/MEMS58180.2024.10439596",
language = "English (US)",
series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "441--444",
booktitle = "IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024",
}