TY - JOUR
T1 - Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer
AU - Hwang, Rosa F.
AU - Wang, Huamin
AU - Lara, Axbal
AU - Gomez, Henry
AU - Chang, Tracy
AU - Sieffert, Nicole
AU - Moon, Younghee
AU - Ram, Sabina
AU - Zimmerman, Stuart
AU - Lee, Jeffrey H.
AU - Pisters, Peter W.T.
AU - Tamm, Eric P.
AU - Fleming, Jason B.
AU - Abbruzzese, James L.
AU - Evans, Douglas B.
N1 - Funding Information:
Supported by the Hamill Foundation, the Lockton Fund for Pancreatic Cancer Research, the Various Donor Fund for Pancreatic Cancer Research, and National Institutes of Health grant CA101936-01 (SPORE in Pancreatic Cancer) at The University of Texas M. D. Anderson Cancer Center.
Funding Information:
The institutional tissue bank, partially funded by our institution®s Cancer Center Support Grant as a shared resource, coordinates the procurement and storage of all biospecimens for research. The facility®s database is a secure web-accessible application that maintains information on all specimens and corresponding patients and protects against unauthorized use of surgical specimens without patient consent.
PY - 2008/5
Y1 - 2008/5
N2 - Background: The integration of biospecimens with reliable clinical data is critical to advance molecular findings from the laboratory to the clinic. We describe the development of an integrated pancreatic tissue bank (PTB) and clinical database for patients with pancreatic cancer and other pancreatic disorders. Methods: A clinical database and PTB were created in 1990 and 2000, respectively, to collect clinical information and biospecimens from patients with suspected or confirmed pancreatic cancer, other pancreatic diseases, and tumors of the duodenum, ampulla of Vater, and distal bile duct. Standard procedures for biospecimen collection and data entry were developed. Results: From 2000 through 2006, the PTB collected 8,061 pancreatic tissue specimens from 620 patients. The most common histologies of pancreatic tumors were pancreatic ductal adenocarcinoma (55.3%) and neuroendocrine carcinoma (16.3%). The biospecimen collection also includes 431 plasma samples, 40 fine-needle aspiration samples, and a tissue microarray containing 85 pancreatic adenocarcinomas and matched normal tissue specimens. The clinical database contains information for 7,647 patients with pancreatic cancer, other pancreatic disorders, and duodenal, ampullary, or bile duct neoplasms. The data are arranged into nine modules: patient, presentation, risk factors, diagnostic imaging, treatment plan, surgery, pathology, postoperative complications, and follow-up. Conclusions: We have established a pancreatic cancer tissue bank with standardized procedures for collection of biospecimens along with a comprehensive multidisciplinary clinical database. The integrated biospecimen bank and clinical database for pancreatic cancer described here can serve as a model from which other groups may develop similar systems.
AB - Background: The integration of biospecimens with reliable clinical data is critical to advance molecular findings from the laboratory to the clinic. We describe the development of an integrated pancreatic tissue bank (PTB) and clinical database for patients with pancreatic cancer and other pancreatic disorders. Methods: A clinical database and PTB were created in 1990 and 2000, respectively, to collect clinical information and biospecimens from patients with suspected or confirmed pancreatic cancer, other pancreatic diseases, and tumors of the duodenum, ampulla of Vater, and distal bile duct. Standard procedures for biospecimen collection and data entry were developed. Results: From 2000 through 2006, the PTB collected 8,061 pancreatic tissue specimens from 620 patients. The most common histologies of pancreatic tumors were pancreatic ductal adenocarcinoma (55.3%) and neuroendocrine carcinoma (16.3%). The biospecimen collection also includes 431 plasma samples, 40 fine-needle aspiration samples, and a tissue microarray containing 85 pancreatic adenocarcinomas and matched normal tissue specimens. The clinical database contains information for 7,647 patients with pancreatic cancer, other pancreatic disorders, and duodenal, ampullary, or bile duct neoplasms. The data are arranged into nine modules: patient, presentation, risk factors, diagnostic imaging, treatment plan, surgery, pathology, postoperative complications, and follow-up. Conclusions: We have established a pancreatic cancer tissue bank with standardized procedures for collection of biospecimens along with a comprehensive multidisciplinary clinical database. The integrated biospecimen bank and clinical database for pancreatic cancer described here can serve as a model from which other groups may develop similar systems.
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U2 - 10.1245/s10434-008-9833-1
DO - 10.1245/s10434-008-9833-1
M3 - Article
C2 - 18256882
AN - SCOPUS:41549165142
SN - 1068-9265
VL - 15
SP - 1356
EP - 1366
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 5
ER -