Development of autoantibody signatures for common cancers

Makoto Kobayashi; Hiroyuki Katayama; Johannes F. Fahrmann; Samir M. Hanash

doi:10.1016/j.smim.2020.101388

Development of autoantibody signatures for common cancers

Makoto Kobayashi, Hiroyuki Katayama, Johannes F. Fahrmann, Samir M. Hanash

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available for the discovery of tumor antigens directed autoantibodies in circulation. Each approach has advantages and limitations for comprehensive discovery of antigenic epitopes. Herein, we review established and novel strategies and methodologies and highlight potential cancer applications.

Original language	English (US)
Article number	101388
Journal	Seminars in immunology
Volume	47
DOIs	https://doi.org/10.1016/j.smim.2020.101388
State	Published - Feb 2020

Keywords

Antigen-antibody complexes
Autoantibody
Biomarker signatures
Cancer early detection

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/j.smim.2020.101388

Cite this

@article{88cb084e99054f958b2060ed2bcf2760,

title = "Development of autoantibody signatures for common cancers",

abstract = "A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available for the discovery of tumor antigens directed autoantibodies in circulation. Each approach has advantages and limitations for comprehensive discovery of antigenic epitopes. Herein, we review established and novel strategies and methodologies and highlight potential cancer applications.",

keywords = "Antigen-antibody complexes, Autoantibody, Biomarker signatures, Cancer early detection",

author = "Makoto Kobayashi and Hiroyuki Katayama and Fahrmann, {Johannes F.} and Hanash, {Samir M.}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = feb,

doi = "10.1016/j.smim.2020.101388",

language = "English (US)",

volume = "47",

journal = "Seminars in immunology",

issn = "1044-5323",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Development of autoantibody signatures for common cancers

AU - Kobayashi, Makoto

AU - Katayama, Hiroyuki

AU - Fahrmann, Johannes F.

AU - Hanash, Samir M.

PY - 2020/2

Y1 - 2020/2

N2 - A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available for the discovery of tumor antigens directed autoantibodies in circulation. Each approach has advantages and limitations for comprehensive discovery of antigenic epitopes. Herein, we review established and novel strategies and methodologies and highlight potential cancer applications.

AB - A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available for the discovery of tumor antigens directed autoantibodies in circulation. Each approach has advantages and limitations for comprehensive discovery of antigenic epitopes. Herein, we review established and novel strategies and methodologies and highlight potential cancer applications.

KW - Antigen-antibody complexes

KW - Autoantibody

KW - Biomarker signatures

KW - Cancer early detection

UR - http://www.scopus.com/inward/record.url?scp=85077654863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077654863&partnerID=8YFLogxK

U2 - 10.1016/j.smim.2020.101388

DO - 10.1016/j.smim.2020.101388

M3 - Review article

C2 - 31924500

AN - SCOPUS:85077654863

SN - 1044-5323

VL - 47

JO - Seminars in immunology

JF - Seminars in immunology

M1 - 101388

ER -

Development of autoantibody signatures for common cancers

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this