Development of CD1d-restricted NKT cells in the mouse thymus

Tao Dao; Donglin Guo; Alexander Ploss; Amy Stolzer; Carolyn Saylor; Tamar E. Boursalian; Jin Seon Im; Derek B. Sant'Angelo

doi:10.1002/eji.200425546

Development of CD1d-restricted NKT cells in the mouse thymus

Tao Dao, Donglin Guo, Alexander Ploss, Amy Stolzer, Carolyn Saylor, Tamar E. Boursalian, Jin Seon Im, Derek B. Sant'Angelo

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4⁺CD8⁺ stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.

Original language	English (US)
Pages (from-to)	3542-3552
Number of pages	11
Journal	European Journal of Immunology
Volume	34
Issue number	12
DOIs	https://doi.org/10.1002/eji.200425546
State	Published - Dec 2004
Externally published	Yes

Keywords

CD1d
T cell receptor
Thymus
iNKT cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1002/eji.200425546

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abstract = "Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4+CD8+ stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.",

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AU - Dao, Tao

AU - Guo, Donglin

AU - Ploss, Alexander

AU - Stolzer, Amy

AU - Saylor, Carolyn

AU - Boursalian, Tamar E.

AU - Im, Jin Seon

AU - Sant'Angelo, Derek B.

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N2 - Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4+CD8+ stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.

AB - Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4+CD8+ stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.

KW - CD1d

KW - T cell receptor

KW - Thymus

KW - iNKT cells

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Development of CD1d-restricted NKT cells in the mouse thymus

Abstract

Keywords

ASJC Scopus subject areas

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