Development of drug resistance in the population of colon cancer cells under the effect of multifunctional protein YB-1

A. V. Vaiman; T. P. Stromskaya; E. Yu Rybalkina; A. V. Sorokin; L. P. Ovchinnikov; A. A. Stavrovskaya

doi:10.1007/s10517-007-0157-0

Development of drug resistance in the population of colon cancer cells under the effect of multifunctional protein YB-1

A. V. Vaiman, T. P. Stromskaya, E. Yu Rybalkina, A. V. Sorokin, L. P. Ovchinnikov, A. A. Stavrovskaya

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effects of YB-1 gene on the expression level of P-glycoprotein and drug resistance of tumor cells were studied in cultured HCT116 colon cancer cells. Transitory transfection of chimeric YB-1/GFP gene rendered HCT116 cells a selective advantage in a medium with vinblastine, which caused translocation of the chimeric protein into cell nuclei. This was paralleled by an increase in the expression of P-glycoprotein (multiple drug resistance protein).

Original language	English (US)
Pages (from-to)	463-466
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	143
Issue number	4
DOIs	https://doi.org/10.1007/s10517-007-0157-0
State	Published - Apr 2007
Externally published	Yes

Keywords

Colorectal cancer
P-glycoprotein
Tumor cells
YB-1 protein

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/s10517-007-0157-0

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title = "Development of drug resistance in the population of colon cancer cells under the effect of multifunctional protein YB-1",

abstract = "The effects of YB-1 gene on the expression level of P-glycoprotein and drug resistance of tumor cells were studied in cultured HCT116 colon cancer cells. Transitory transfection of chimeric YB-1/GFP gene rendered HCT116 cells a selective advantage in a medium with vinblastine, which caused translocation of the chimeric protein into cell nuclei. This was paralleled by an increase in the expression of P-glycoprotein (multiple drug resistance protein).",

keywords = "Colorectal cancer, P-glycoprotein, Tumor cells, YB-1 protein",

author = "Vaiman, {A. V.} and Stromskaya, {T. P.} and Rybalkina, {E. Yu} and Sorokin, {A. V.} and Ovchinnikov, {L. P.} and Stavrovskaya, {A. A.}",

note = "Funding Information: The study was partially supported by the Russian Foundation for Basic Research (grant No. 04- 04-48613) and grants within the framework of Program of the Board of the Russian Academy of Sciences “Molecular and Cellular Biology” and “Fundamental Sciences for Medicine”.",

year = "2007",

month = apr,

doi = "10.1007/s10517-007-0157-0",

language = "English (US)",

volume = "143",

pages = "463--466",

journal = "Bulletin of Experimental Biology and Medicine",

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T1 - Development of drug resistance in the population of colon cancer cells under the effect of multifunctional protein YB-1

AU - Vaiman, A. V.

AU - Stromskaya, T. P.

AU - Rybalkina, E. Yu

AU - Sorokin, A. V.

AU - Ovchinnikov, L. P.

AU - Stavrovskaya, A. A.

N1 - Funding Information: The study was partially supported by the Russian Foundation for Basic Research (grant No. 04- 04-48613) and grants within the framework of Program of the Board of the Russian Academy of Sciences “Molecular and Cellular Biology” and “Fundamental Sciences for Medicine”.

PY - 2007/4

Y1 - 2007/4

N2 - The effects of YB-1 gene on the expression level of P-glycoprotein and drug resistance of tumor cells were studied in cultured HCT116 colon cancer cells. Transitory transfection of chimeric YB-1/GFP gene rendered HCT116 cells a selective advantage in a medium with vinblastine, which caused translocation of the chimeric protein into cell nuclei. This was paralleled by an increase in the expression of P-glycoprotein (multiple drug resistance protein).

AB - The effects of YB-1 gene on the expression level of P-glycoprotein and drug resistance of tumor cells were studied in cultured HCT116 colon cancer cells. Transitory transfection of chimeric YB-1/GFP gene rendered HCT116 cells a selective advantage in a medium with vinblastine, which caused translocation of the chimeric protein into cell nuclei. This was paralleled by an increase in the expression of P-glycoprotein (multiple drug resistance protein).

KW - Colorectal cancer

KW - P-glycoprotein

KW - Tumor cells

KW - YB-1 protein

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Development of drug resistance in the population of colon cancer cells under the effect of multifunctional protein YB-1

Abstract

Keywords

ASJC Scopus subject areas

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