Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

Hartmut Döhner; Andrew H. Wei; Frederick R. Appelbaum; Charles Craddock; Courtney D. DiNardo; Hervé Dombret; Benjamin L. Ebert; Pierre Fenaux; Lucy A. Godley; Robert P. Hasserjian; Richard A. Larson; Ross L. Levine; Yasushi Miyazaki; Dietger Niederwieser; Gert Ossenkoppele; Christoph Röllig; Jorge Sierra; Eytan M. Stein; Martin S. Tallman; Hwei Fang Tien; Jianxiang Wang; Agnieszka Wierzbowska; Bob Löwenberg

doi:10.1182/blood.2022016867

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

Hartmut Döhner, Andrew H. Wei, Frederick R. Appelbaum, Charles Craddock, Courtney D. DiNardo, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Lucy A. Godley, Robert P. Hasserjian, Richard A. Larson, Ross L. Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M. Stein, Martin S. Tallman, Hwei Fang TienJianxiang Wang, Agnieszka Wierzbowska, Bob Löwenberg

Leukemia

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793 Scopus citations

Abstract

The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults are widely recognized among physicians and investigators. There have been major advances in our understanding of AML, including new knowledge about the molecular pathogenesis of AML, leading to an update of the disease classification, technological progress in genomic diagnostics and assessment of measurable residual disease, and the successful development of new therapeutic agents, such as FLT3, IDH1, IDH2, and BCL2 inhibitors. These advances have prompted this update that includes a revised ELN genetic risk classification, revised response criteria, and treatment recommendations.

Original language	English (US)
Pages (from-to)	1345-1377
Number of pages	33
Journal	Blood
Volume	140
Issue number	12
DOIs	https://doi.org/10.1182/blood.2022016867
State	Published - Sep 22 2022

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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Döhner, H., Wei, A. H., Appelbaum, F. R., Craddock, C., DiNardo, C. D., Dombret, H., Ebert, B. L., Fenaux, P., Godley, L. A., Hasserjian, R. P., Larson, R. A., Levine, R. L., Miyazaki, Y., Niederwieser, D., Ossenkoppele, G., Röllig, C., Sierra, J., Stein, E. M., Tallman, M. S., ... Löwenberg, B. (2022). Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood, 140(12), 1345-1377. https://doi.org/10.1182/blood.2022016867

Döhner, H, Wei, AH, Appelbaum, FR, Craddock, C, DiNardo, CD, Dombret, H, Ebert, BL, Fenaux, P, Godley, LA, Hasserjian, RP, Larson, RA, Levine, RL, Miyazaki, Y, Niederwieser, D, Ossenkoppele, G, Röllig, C, Sierra, J, Stein, EM, Tallman, MS, Tien, HF, Wang, J, Wierzbowska, A & Löwenberg, B 2022, 'Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN', Blood, vol. 140, no. 12, pp. 1345-1377. https://doi.org/10.1182/blood.2022016867

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title = "Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN",

abstract = "The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults are widely recognized among physicians and investigators. There have been major advances in our understanding of AML, including new knowledge about the molecular pathogenesis of AML, leading to an update of the disease classification, technological progress in genomic diagnostics and assessment of measurable residual disease, and the successful development of new therapeutic agents, such as FLT3, IDH1, IDH2, and BCL2 inhibitors. These advances have prompted this update that includes a revised ELN genetic risk classification, revised response criteria, and treatment recommendations.",

author = "Hartmut D{\"o}hner and Wei, {Andrew H.} and Appelbaum, {Frederick R.} and Charles Craddock and DiNardo, {Courtney D.} and Herv{\'e} Dombret and Ebert, {Benjamin L.} and Pierre Fenaux and Godley, {Lucy A.} and Hasserjian, {Robert P.} and Larson, {Richard A.} and Levine, {Ross L.} and Yasushi Miyazaki and Dietger Niederwieser and Gert Ossenkoppele and Christoph R{\"o}llig and Jorge Sierra and Stein, {Eytan M.} and Tallman, {Martin S.} and Tien, {Hwei Fang} and Jianxiang Wang and Agnieszka Wierzbowska and Bob L{\"o}wenberg",

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AU - Döhner, Hartmut

AU - Wei, Andrew H.

AU - Appelbaum, Frederick R.

AU - Craddock, Charles

AU - DiNardo, Courtney D.

AU - Dombret, Hervé

AU - Ebert, Benjamin L.

AU - Fenaux, Pierre

AU - Godley, Lucy A.

AU - Hasserjian, Robert P.

AU - Larson, Richard A.

AU - Levine, Ross L.

AU - Miyazaki, Yasushi

AU - Niederwieser, Dietger

AU - Ossenkoppele, Gert

AU - Röllig, Christoph

AU - Sierra, Jorge

AU - Stein, Eytan M.

AU - Tallman, Martin S.

AU - Tien, Hwei Fang

AU - Wang, Jianxiang

AU - Wierzbowska, Agnieszka

AU - Löwenberg, Bob

PY - 2022/9/22

Y1 - 2022/9/22

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AB - The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults are widely recognized among physicians and investigators. There have been major advances in our understanding of AML, including new knowledge about the molecular pathogenesis of AML, leading to an update of the disease classification, technological progress in genomic diagnostics and assessment of measurable residual disease, and the successful development of new therapeutic agents, such as FLT3, IDH1, IDH2, and BCL2 inhibitors. These advances have prompted this update that includes a revised ELN genetic risk classification, revised response criteria, and treatment recommendations.

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Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

Abstract

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