TY - JOUR
T1 - Diagnostic and therapeutic potential of poly(benzyl L‐glutamate)
AU - Yang, David J.
AU - Li, Chun
AU - Nikiforow, Sarah
AU - Gretzer, Matthew B.
AU - Kuang, Li‐Ren ‐R
AU - Lopez, Mona S.
AU - Vargas, Karen
AU - Wallace, Sidney
PY - 1994/3
Y1 - 1994/3
N2 - Poly(benzyl L‐glutamate) (PBLG) microcapsules, prepared by a solvent evaporation technique for intravenous injection, are evaluated for their potential use in diagnostic computed tomographic enhancement of liver images. The smaller microcapsules, <3 μm, loaded with a radiopaque contrast material, ethyl iopanoate (IOPAE), produced prolonged opacification of the liver when delivered intravenously. In vivo tissue distribution studies of PBLG‐131I‐IOPAE (5 μCi/rat, iv) showed that liver had the highest uptake (percent of injected dose/g of tissue) among other organs 24 h postinjection. An in vitro estrogen receptor assay in pig uteri indicated that PBLG ocnjugated with estrone did not interfere with estrogen receptor affinity, suggesting the estrogen therapy potential of PBLG–estrone.
AB - Poly(benzyl L‐glutamate) (PBLG) microcapsules, prepared by a solvent evaporation technique for intravenous injection, are evaluated for their potential use in diagnostic computed tomographic enhancement of liver images. The smaller microcapsules, <3 μm, loaded with a radiopaque contrast material, ethyl iopanoate (IOPAE), produced prolonged opacification of the liver when delivered intravenously. In vivo tissue distribution studies of PBLG‐131I‐IOPAE (5 μCi/rat, iv) showed that liver had the highest uptake (percent of injected dose/g of tissue) among other organs 24 h postinjection. An in vitro estrogen receptor assay in pig uteri indicated that PBLG ocnjugated with estrone did not interfere with estrogen receptor affinity, suggesting the estrogen therapy potential of PBLG–estrone.
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U2 - 10.1002/jps.2600830312
DO - 10.1002/jps.2600830312
M3 - Article
C2 - 7515964
AN - SCOPUS:0028352770
SN - 0022-3549
VL - 83
SP - 328
EP - 331
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 3
ER -