Diagnostic and therapeutic value of intracellular biomarker testing in chronic pain

Alice L. Ye; Emily W. Sudek; Daniela Magdaleno; Carlos J. Roldan

doi:10.2217/pmt-2023-0080

Diagnostic and therapeutic value of intracellular biomarker testing in chronic pain

Alice L. Ye, Emily W. Sudek, Daniela Magdaleno, Carlos J. Roldan

Pain Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Micronutrient and metabolic compound supplementation as a method of treating chronic pain is not well understood. Case: A 58 year-old woman presented with refractory painful neuropathy. She did not respond to conservative treatment and was seeking spinal cord stimulator implantation. She underwent a biomarker panel that revealed low intracellular levels of multiple compounds. As she supplemented her deficiencies, her symptoms fully resolved, and the implant was no longer indicated. Discussion: Micronutrient and metabolic compound testing could potentially expand non-invasive treatment options for patients with refractory chronic pain. Caution should be exercised given limited regulatory oversight in the supplement industry and actively ongoing nutritional research. Conclusion: Biomarker testing panels may be a useful adjunct in the management of refractory neuropathic pain.

Original language	English (US)
Pages (from-to)	21-27
Number of pages	7
Journal	Pain management
Volume	14
Issue number	1
DOIs	https://doi.org/10.2217/pmt-2023-0080
State	Published - Jan 1 2024

Keywords

Chronic pain
Metabolic compounds
Micronutrients
Neuropathic pain
Peripheral neuropathy

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.2217/pmt-2023-0080

Cite this

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abstract = "Aim: Micronutrient and metabolic compound supplementation as a method of treating chronic pain is not well understood. Case: A 58 year-old woman presented with refractory painful neuropathy. She did not respond to conservative treatment and was seeking spinal cord stimulator implantation. She underwent a biomarker panel that revealed low intracellular levels of multiple compounds. As she supplemented her deficiencies, her symptoms fully resolved, and the implant was no longer indicated. Discussion: Micronutrient and metabolic compound testing could potentially expand non-invasive treatment options for patients with refractory chronic pain. Caution should be exercised given limited regulatory oversight in the supplement industry and actively ongoing nutritional research. Conclusion: Biomarker testing panels may be a useful adjunct in the management of refractory neuropathic pain.",

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AU - Ye, Alice L.

AU - Sudek, Emily W.

AU - Magdaleno, Daniela

AU - Roldan, Carlos J.

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AB - Aim: Micronutrient and metabolic compound supplementation as a method of treating chronic pain is not well understood. Case: A 58 year-old woman presented with refractory painful neuropathy. She did not respond to conservative treatment and was seeking spinal cord stimulator implantation. She underwent a biomarker panel that revealed low intracellular levels of multiple compounds. As she supplemented her deficiencies, her symptoms fully resolved, and the implant was no longer indicated. Discussion: Micronutrient and metabolic compound testing could potentially expand non-invasive treatment options for patients with refractory chronic pain. Caution should be exercised given limited regulatory oversight in the supplement industry and actively ongoing nutritional research. Conclusion: Biomarker testing panels may be a useful adjunct in the management of refractory neuropathic pain.

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KW - Metabolic compounds

KW - Micronutrients

KW - Neuropathic pain

KW - Peripheral neuropathy

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Diagnostic and therapeutic value of intracellular biomarker testing in chronic pain

Abstract

Keywords

ASJC Scopus subject areas

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