Diagnostic applications of nuclear medicine: Sarcomas

Sumit Gupta; Douglas J. Harrison; Marguerite T. Parisi; Barry L. Shulkin

doi:10.1007/978-3-031-05494-5_92

Diagnostic applications of nuclear medicine: Sarcomas

Sumit Gupta, Douglas J. Harrison, Marguerite T. Parisi, Barry L. Shulkin

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Bone and soft tissue tumors, while rare, account for a relatively large proportion of pediatric cancer diagnoses. The role for [¹⁸F]FDG PET/CT in the staging and prognostication of pediatric s arcomas remains an active area for research and topic of debate. [¹⁸F]FDG PET/CT clearly maintains a significant role in the detection of osseous metastasis in osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma; however, it lacks the sensitivity and specificity in detecting pulmonary metastasis when compared to conventional CT scan. [¹⁸F]FDG PET/CT predicts histologic response in osteosarcoma; however, more studies are needed to determine whether it can predict outcome in other pediatric sarcomas as a whole. While [¹⁸F]FDG PET/CT is becoming increasingly utilized in the staging of pediatric sarcomas, more research will be needed to fully understand how best to incorporate its use in the management of, or as a prognostic tool in, pediatric and young adult bone and soft tissue sarcomas.

Original language	English (US)
Title of host publication	Nuclear Oncology
Subtitle of host publication	From Pathophysiology to Clinical Applications
Publisher	Springer International Publishing
Pages	1213-1234
Number of pages	22
ISBN (Electronic)	9783031054945
ISBN (Print)	9783031054938
DOIs	https://doi.org/10.1007/978-3-031-05494-5_92
State	Published - Oct 4 2022

Keywords

Ewing
Malignancy
Osteosarcoma
Outcome
Pediatric
PET/CT
Rhabdomyosarcoma
Sarcomas
Staging
[F]FDG

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-031-05494-5_92

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title = "Diagnostic applications of nuclear medicine: Sarcomas",

abstract = "Bone and soft tissue tumors, while rare, account for a relatively large proportion of pediatric cancer diagnoses. The role for [18F]FDG PET/CT in the staging and prognostication of pediatric s arcomas remains an active area for research and topic of debate. [18F]FDG PET/CT clearly maintains a significant role in the detection of osseous metastasis in osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma; however, it lacks the sensitivity and specificity in detecting pulmonary metastasis when compared to conventional CT scan. [18F]FDG PET/CT predicts histologic response in osteosarcoma; however, more studies are needed to determine whether it can predict outcome in other pediatric sarcomas as a whole. While [18F]FDG PET/CT is becoming increasingly utilized in the staging of pediatric sarcomas, more research will be needed to fully understand how best to incorporate its use in the management of, or as a prognostic tool in, pediatric and young adult bone and soft tissue sarcomas.",

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author = "Sumit Gupta and Harrison, {Douglas J.} and Parisi, {Marguerite T.} and Shulkin, {Barry L.}",

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N2 - Bone and soft tissue tumors, while rare, account for a relatively large proportion of pediatric cancer diagnoses. The role for [18F]FDG PET/CT in the staging and prognostication of pediatric s arcomas remains an active area for research and topic of debate. [18F]FDG PET/CT clearly maintains a significant role in the detection of osseous metastasis in osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma; however, it lacks the sensitivity and specificity in detecting pulmonary metastasis when compared to conventional CT scan. [18F]FDG PET/CT predicts histologic response in osteosarcoma; however, more studies are needed to determine whether it can predict outcome in other pediatric sarcomas as a whole. While [18F]FDG PET/CT is becoming increasingly utilized in the staging of pediatric sarcomas, more research will be needed to fully understand how best to incorporate its use in the management of, or as a prognostic tool in, pediatric and young adult bone and soft tissue sarcomas.

AB - Bone and soft tissue tumors, while rare, account for a relatively large proportion of pediatric cancer diagnoses. The role for [18F]FDG PET/CT in the staging and prognostication of pediatric s arcomas remains an active area for research and topic of debate. [18F]FDG PET/CT clearly maintains a significant role in the detection of osseous metastasis in osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma; however, it lacks the sensitivity and specificity in detecting pulmonary metastasis when compared to conventional CT scan. [18F]FDG PET/CT predicts histologic response in osteosarcoma; however, more studies are needed to determine whether it can predict outcome in other pediatric sarcomas as a whole. While [18F]FDG PET/CT is becoming increasingly utilized in the staging of pediatric sarcomas, more research will be needed to fully understand how best to incorporate its use in the management of, or as a prognostic tool in, pediatric and young adult bone and soft tissue sarcomas.

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ER -

Diagnostic applications of nuclear medicine: Sarcomas

Abstract

Keywords

ASJC Scopus subject areas

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