Dibutyryl cyclic adenosine monophosphate: Effect on radiosensitivity of tumors and normal tissues in mice

N. B. Dubravsky; N. Hunter; K. Mason; H. R. Withers

doi:10.1148/126.3.799

Dibutyryl cyclic adenosine monophosphate: Effect on radiosensitivity of tumors and normal tissues in mice

N. B. Dubravsky, N. Hunter, K. Mason, H. R. Withers

Experimental Radiation Oncology

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Abstract

The effect of dibutyryl cyclic adenosine monophosphate (db-cAMP, 30 mg/kg), injected into mice before irradiation, on the radiation sensitivity of various tissues was investigated. Survival of proliferating hair follicles, small gut stem cells, fibrosarcoma (FSa) micrometastases in the lungs, and two different mammary carcinomas, as assayed by the TCD₅₀ method, were studied. Intraperitoneal injection of db-cAMP before irradiation resulted in higher survival of hair follicles irradiated on the third day after plucking. Stem cells in the small gut showed increased survival if irradiated 4 hr after injection. There was no effect on the survival of FSa micrometastases by preinjection and the TCD₅₀/120 days of the mammary carcinomas was not altered.

Original language	English (US)
Pages (from-to)	799-802
Number of pages	4
Journal	Radiology
Volume	126
Issue number	3
DOIs	https://doi.org/10.1148/126.3.799
State	Published - 1978

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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title = "Dibutyryl cyclic adenosine monophosphate: Effect on radiosensitivity of tumors and normal tissues in mice",

abstract = "The effect of dibutyryl cyclic adenosine monophosphate (db-cAMP, 30 mg/kg), injected into mice before irradiation, on the radiation sensitivity of various tissues was investigated. Survival of proliferating hair follicles, small gut stem cells, fibrosarcoma (FSa) micrometastases in the lungs, and two different mammary carcinomas, as assayed by the TCD50 method, were studied. Intraperitoneal injection of db-cAMP before irradiation resulted in higher survival of hair follicles irradiated on the third day after plucking. Stem cells in the small gut showed increased survival if irradiated 4 hr after injection. There was no effect on the survival of FSa micrometastases by preinjection and the TCD50/120 days of the mammary carcinomas was not altered.",

author = "Dubravsky, {N. B.} and N. Hunter and K. Mason and Withers, {H. R.}",

year = "1978",

doi = "10.1148/126.3.799",

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T2 - Effect on radiosensitivity of tumors and normal tissues in mice

AU - Dubravsky, N. B.

AU - Hunter, N.

AU - Mason, K.

AU - Withers, H. R.

PY - 1978

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AB - The effect of dibutyryl cyclic adenosine monophosphate (db-cAMP, 30 mg/kg), injected into mice before irradiation, on the radiation sensitivity of various tissues was investigated. Survival of proliferating hair follicles, small gut stem cells, fibrosarcoma (FSa) micrometastases in the lungs, and two different mammary carcinomas, as assayed by the TCD50 method, were studied. Intraperitoneal injection of db-cAMP before irradiation resulted in higher survival of hair follicles irradiated on the third day after plucking. Stem cells in the small gut showed increased survival if irradiated 4 hr after injection. There was no effect on the survival of FSa micrometastases by preinjection and the TCD50/120 days of the mammary carcinomas was not altered.

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Dibutyryl cyclic adenosine monophosphate: Effect on radiosensitivity of tumors and normal tissues in mice

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